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Mayr, C; Ocker, M; Ritter, M; Pichler, M; Neureiter, D; Kiesslich, T.
Biliary tract cancer stem cells - translational options and challenges.
World J Gastroenterol. 2017; 23(14):2470-2482 Doi: 10.3748/wjg.v23.i14.2470 [OPEN ACCESS]
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Co-Autor*innen der Med Uni Graz
Pichler Martin

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Management of biliary tract cancer remains challenging. Tumors show high recurrence rates and therapeutic resistance, leading to dismal prognosis and short survival. The cancer stem cell model states that a tumor is a heterogeneous conglomerate of cells, in which a certain subpopulation of cells - the cancer stem cells - possesses stem cell properties. Cancer stem cells have high clinical relevance due to their potential contributions to development, progression and aggressiveness as well as recurrence and metastasis of malignant tumors. Consequently, reliable identification of as well as pharmacological intervention with cancer stem cells is an intensively investigated and promising research field. The involvement of cancer stem cells in biliary tract cancer is likely as a number of studies demonstrated their existence and the obvious clinical relevance of several established cancer stem cell markers in biliary tract cancer models and tissues. In the present article, we review and discuss the currently available literature addressing the role of putative cancer stem cells in biliary tract cancer as well as the connection between known contributors of biliary tract tumorigenesis such as oncogenic signaling pathways, micro-RNAs and the tumor microenvironment with cancer stem cells.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Antineoplastic Agents - therapeutic use
Biliary Tract Neoplasms - drug therapy
Biliary Tract Neoplasms - metabolism
Biliary Tract Neoplasms - pathology
Biomarkers, Tumor - metabolism
Cell Lineage -
Cell Movement -
Cell Proliferation -
Humans -
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - pathology
Phenotype -
Signal Transduction -
Tumor Microenvironment -

Find related publications in this database (Keywords)
Biliary tract cancer
cancer stem cells
Cancer stem cell markers
Tumor microenvironment
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