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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Verheyen, N; Fahrleitner-Pammer, A; Belyavskiy, E; Gruebler, MR; Dimai, HP; Amrein, K; Ablasser, K; Martensen, J; Catena, C; Pieske-Kraigher, E; Colantonio, C; Voelkl, J; Lang, F; Alesutan, I; Meinitzer, A; März, W; Brussee, H; Pieske, B; Pilz, S; Tomaschitz, A.
Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: The EPATH trial.
PLoS One. 2017; 12(4):e0173799-e0173799 Doi: 10.1371/journal.pone.0173799 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Verheyen Nicolas Dominik
Co-Autor*innen der Med Uni Graz
Ablasser Klemens
Amrein Karin
Belyavskiy Evgeny
Brussee Helmut
Colantonio Caterina
Dimai Hans Peter
Fahrleitner-Pammer Astrid
Martensen Johann
März Winfried
Meinitzer Andreas
Pieske Burkert Mathias
Pilz Stefan
Tomaschitz Andreas

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Observational studies suggested a link between bone disease and left ventricular (LV) dysfunction that may be pronounced in hyperparathyroid conditions. We therefore aimed to test the hypothesis that circulating markers of bone turnover correlate with LV function in a cohort of patients with primary hyperparathyroidism (pHPT). Cross-sectional data of 155 subjects with pHPT were analyzed who participated in the "Eplerenone in Primary Hyperparathyroidism" (EPATH) Trial. Multivariate linear regression analyses with LV ejection fraction (LVEF, systolic function) or peak early transmitral filling velocity (e', diastolic function) as dependent variables and N-terminal propeptide of procollagen type 1 (P1NP), osteocalcin (OC), bone-specific alkaline phosphatase (BALP), or beta-crosslaps (CTX) as the respective independent variable were performed. Analyses were additionally adjusted for plasma parathyroid hormone, plasma calcium, age, sex, HbA1c, body mass index, mean 24-hours systolic blood pressure, smoking status, estimated glomerular filtration rate, antihypertensive treatment, osteoporosis treatment, 25-hydroxy vitamin D and N-terminal pro-brain B-type natriuretic peptide. Independent relationships were observed between P1NP and LVEF (adjusted β-coefficient = 0.201, P = 0.035) and e' (β = 0.188, P = 0.042), respectively. OC (β = 0.192, P = 0.039) and BALP (β = 0.198, P = 0.030) were each independently related with e'. CTX showed no correlations with LVEF or e'. In conclusion, high bone formation markers were independently and paradoxically related with better LV diastolic and, partly, better systolic function, in the setting of pHPT. Potentially cardio-protective properties of stimulated bone formation in the context of hyperparathyroidism should be explored in future studies.
Find related publications in this database (using NLM MeSH Indexing)
Age Factors -
Aged -
Alkaline Phosphatase - blood
Biomarkers - blood
Bone Remodeling -
Calcium - blood
Cross-Sectional Studies -
Female -
Glycated Hemoglobin A - metabolism
Humans -
Hyperparathyroidism - blood
Hyperparathyroidism - physiopathology
Male -
Middle Aged -
Osteocalcin - blood
Parathyroid Hormone - blood
Peptide Fragments - blood
Procollagen - blood
Ventricular Function, Left -

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