Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Smolle, MA; Bauernhofer, T; Pummer, K; Calin, GA; Pichler, M.
Current Insights into Long Non-Coding RNAs (LncRNAs) in Prostate Cancer.
Int J Mol Sci. 2017; 18(2): Doi: 10.3390/ijms18020473 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Führende Autor*innen der Med Uni Graz: Pichler Martin; Smolle Maria Anna
Co-Autor*innen der Med Uni Graz: Bauernhofer Thomas; Pummer Karl
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Abstract:: The importance of long non-coding RNAs (lncRNAs) in the pathogenesis of various malignancies has been uncovered over the last few years. Their dysregulation often contributes to or is a result of tumour progression. In prostate cancer, the most common malignancy in men, lncRNAs can promote castration resistance, cell proliferation, invasion, and metastatic spread. Expression patterns of lncRNAs often change during tumour progression; their expression levels may constantly rise (e.g., HOX transcript antisense RNA, HOTAIR), or steadily decrease (e.g., downregulated RNA in cancer, DRAIC). In prostate cancer, lncRNAs likewise have diagnostic (e.g., prostate cancer antigen 3, PCA3), prognostic (e.g., second chromosome locus associated with prostate-1, SChLAP1), and predictive (e.g., metastasis-associated lung adenocarcinoma transcript-1, MALAT-1) functions. Considering their dynamic role in prostate cancer, lncRNAs may also serve as therapeutic targets, helping to prevent development of castration resistance, maintain stable disease, and prohibit metastatic spread.
Find related publications in this database (using NLM MeSH Indexing): Biomarkers, Tumor -; Cell Transformation, Neoplastic - genetics; Drug Resistance, Neoplasm - genetics; Gene Expression Regulation, Neoplastic -; Humans -; Male -; Prognosis -; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - therapy; Prostatic Neoplasms, Castration-Resistant - diagnosis; Prostatic Neoplasms, Castration-Resistant - genetics; Prostatic Neoplasms, Castration-Resistant - metabolism; Prostatic Neoplasms, Castration-Resistant - therapy; RNA, Long Noncoding - genetics
Find related publications in this database (Keywords): long non-coding RNAs; prostate cancer; carcinogenesis