Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Baranyi, A; Amouzadeh-Ghadikolai, O; Lewinski, DV; Breitenecker, RJ; Stojakovic, T; März, W; Robier, C; Rothenhäusler, HB; Mangge, H; Meinitzer, A.
Beta-trace Protein as a new non-invasive immunological Marker for Quinolinic Acid-induced impaired Blood-Brain Barrier Integrity.
Sci Rep. 2017; 7(4):43642-43642
Doi: 10.1038/srep43642
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- Führende Autor*innen der Med Uni Graz
- Baranyi Andreas
- von Lewinski Dirk
- Co-Autor*innen der Med Uni Graz
- Mangge Harald
- März Winfried
- Meinitzer Andreas
- Robier Christoph
- Rothenhäusler Hans-Bernd
- Stojakovic Tatjana
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- Abstract:
- Quinolinic acid, a macrophage/microglia-derived excitotoxin fulfills a plethora of functions such as neurotoxin, gliotoxin, and proinflammatory mediator, and it alters the integrity and cohesion of the blood-brain barrier in several pathophysiological states. Beta-trace protein (BTP), a monomeric glycoprotein, is known to indicate cerebrospinal fluid leakage. Thus, the prior aim of this study was to investigate whether BTP might non-invasively indicate quinolinic acid-induced impaired blood-brain barrier integrity. The research hypotheses were tested in three subsamples with different states of immune activation (patients with HCV-infection and interferon-α, patients with major depression, and healthy controls). BTP has also been described as a sensitive marker in detecting impaired renal function. Thus, the renal function has been considered. Our study results revealed highest quinolinic acid and highest BTP- levels in the subsample of patients with HCV in comparison with the other subsamples with lower or no immune activation (quinolinic acid: F = 21.027, p < 0.001 [ANOVA]; BTP: F = 6.792, p < 0.01 [ANOVA]). In addition, a two-step hierarchical linear regression model showed that significant predictors of BTP levels are quinolinic acid, glomerular filtration rate and age. The neurotoxin quinolinic acid may impair blood-brain barrier integrity. BTP might be a new non-invasive biomarker to indicate quinolinic acid-induced impaired blood-brain barrier integrity.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biomarkers -
- Blood-Brain Barrier - drug effects
- Blood-Brain Barrier - immunology
- Blood-Brain Barrier - metabolism
- Female -
- Glomerular Filtration Rate -
- Humans -
- Intramolecular Oxidoreductases - blood
- Intramolecular Oxidoreductases - immunology
- Intramolecular Oxidoreductases - metabolism
- Lipocalins - blood
- Lipocalins - immunology
- Lipocalins - metabolism
- Male -
- Middle Aged -
- Neurotoxins - adverse effects
- Quinolinic Acid - adverse effects
- Renal Insufficiency, Chronic - complications
- Renal Insufficiency, Chronic - drug therapy
- Renal Insufficiency, Chronic - etiology
- Renal Insufficiency, Chronic - metabolism