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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Baranyi, A; Amouzadeh-Ghadikolai, O; Lewinski, DV; Breitenecker, RJ; Stojakovic, T; März, W; Robier, C; Rothenhäusler, HB; Mangge, H; Meinitzer, A.
Beta-trace Protein as a new non-invasive immunological Marker for Quinolinic Acid-induced impaired Blood-Brain Barrier Integrity.
Sci Rep. 2017; 7(4):43642-43642 Doi: 10.1038/srep43642 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Baranyi Andreas
von Lewinski Dirk
Co-Autor*innen der Med Uni Graz
Mangge Harald
März Winfried
Meinitzer Andreas
Robier Christoph
Rothenhäusler Hans-Bernd
Stojakovic Tatjana

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Quinolinic acid, a macrophage/microglia-derived excitotoxin fulfills a plethora of functions such as neurotoxin, gliotoxin, and proinflammatory mediator, and it alters the integrity and cohesion of the blood-brain barrier in several pathophysiological states. Beta-trace protein (BTP), a monomeric glycoprotein, is known to indicate cerebrospinal fluid leakage. Thus, the prior aim of this study was to investigate whether BTP might non-invasively indicate quinolinic acid-induced impaired blood-brain barrier integrity. The research hypotheses were tested in three subsamples with different states of immune activation (patients with HCV-infection and interferon-α, patients with major depression, and healthy controls). BTP has also been described as a sensitive marker in detecting impaired renal function. Thus, the renal function has been considered. Our study results revealed highest quinolinic acid and highest BTP- levels in the subsample of patients with HCV in comparison with the other subsamples with lower or no immune activation (quinolinic acid: F = 21.027, p < 0.001 [ANOVA]; BTP: F = 6.792, p < 0.01 [ANOVA]). In addition, a two-step hierarchical linear regression model showed that significant predictors of BTP levels are quinolinic acid, glomerular filtration rate and age. The neurotoxin quinolinic acid may impair blood-brain barrier integrity. BTP might be a new non-invasive biomarker to indicate quinolinic acid-induced impaired blood-brain barrier integrity.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Biomarkers -
Blood-Brain Barrier - drug effects
Blood-Brain Barrier - immunology
Blood-Brain Barrier - metabolism
Female -
Glomerular Filtration Rate -
Humans -
Intramolecular Oxidoreductases - blood
Intramolecular Oxidoreductases - immunology
Intramolecular Oxidoreductases - metabolism
Lipocalins - blood
Lipocalins - immunology
Lipocalins - metabolism
Male -
Middle Aged -
Neurotoxins - adverse effects
Quinolinic Acid - adverse effects
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - drug therapy
Renal Insufficiency, Chronic - etiology
Renal Insufficiency, Chronic - metabolism

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