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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid

Langner, C.
Precursors of gastric cancer : Dysplasia and adenoma].
Pathologe. 2017; 38(2):67-74
Web of Science PubMed FullText FullText_MUG

 

Autor/innen der Med Uni Graz:
Langner Cord
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Abstract:
Gastric cancer develops from preneoplastic and early neoplastic precursor lesions. In particular, the intestinal type according to the Lauren classification is driven by chronic inflammation and progresses via a chronic gastritis - atrophy/metaplasia - dysplasia - carcinoma sequence. Staging of the extent of atrophy (OLGA) or intestinal metaplasia (OLGIM) enables risk stratification and determines follow-up investigations according to the management of precancerous conditions and lesions in the stomach (MAPS) international guidelines. True adenomatous lesions are relatively rare in the stomach. Three major types need to be considered: the intestinal type (tubular, tubulovillous and villous), the foveolar type (with superficial gastric differentiation) and the pyloric gland adenoma (with deep gastric differentiation). The intestinal type is the most common and needs to be differentiated from nonneoplastic polypoid regenerative hyperplasia, but also from well-differentiated tubular adenocarcinoma.

Find related publications in this database (Keywords)
Precancerous lesion
Risk stratification
Familial gastric cancer
Histopathology
Stomach
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