Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ribitsch, W; Schilcher, G; Quehenberger, F; Pilz, S; Portugaller, RH; Truschnig-Wilders, M; Zweiker, R; Brodmann, M; Stiegler, P; Rosenkranz, AR; Pickering, JW; Horina, JH.
Neutrophil gelatinase-associated lipocalin (NGAL) fails as an early predictor of contrast induced nephropathy in chronic kidney disease (ANTI-CI-AKI study).
Sci Rep. 2017; 7(6):41300-41300
Doi: 10.1038/srep41300
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- Führende Autor*innen der Med Uni Graz
- Ribitsch Werner
- Schilcher Gernot
- Co-Autor*innen der Med Uni Graz
- Brodmann Marianne
- Horina Joerg
- Pilz Stefan
- Portugaller Rupert
- Quehenberger Franz
- Rosenkranz Alexander
- Stiegler Philipp
- Truschnig-Wilders Martini
- Zweiker Robert
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- Abstract:
- The aim of the study was to evaluate the diagnostic accuracy of urinary neutrophil gelatinase- associated lipocalin (uNGAL) in patients with chronic kidney disease (CKD) as an early biomarker for contrast induced acute kidney injury (CI-AKI) and to investigate whether patients with an uNGAL increase might benefit from an additional intravenous volume expansion with regard to CI-AKI-incidence. We performed a prospective randomized controlled trial in 617 CKD-patients undergoing intra-arterial angiography. Urinary NGAL was measured the day before and 4-6hrs after angiography. In the event of a significant rise of uNGAL patients were randomized either into Group A, who received intravenous saline post procedure or Group B, who did not receive post-procedural i.v. fluids. Ten patients (1.62%) exhibited a significant rise of uNGAL after angiography and were randomized of whom one developed a CI-AKI. In the entire cohort the incidence of CI-AKI was 9.4% (58 patients) resulting in a specificity of 98.4% (95% CI: 97.0-99.3%) and a sensitivity of 1.72% (95% CI: 0.044-9.2%) of uNGAL for the diagnosis of CI-AKI. In this study uNGAL failed to predict CI-AKI and was an inadequate triage tool to guide an early intervention strategy to prevent CI-AKI. URL: http://www.clinicaltrials.gov. Unique identifier: NCT01292317.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Kidney Injury - chemically induced
- Acute Kidney Injury - pathology
- Acute Kidney Injury - urine
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers - urine
- Contrast Media - adverse effects
- Female -
- Humans -
- Lipocalin-2 - urine
- Male -
- Middle Aged -
- Prognosis -
- Prospective Studies -
- Renal Insufficiency, Chronic - pathology
- Renal Insufficiency, Chronic - urine