Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Baranyi, A; Amouzadeh-Ghadikolai, O; von Lewinski, D; Rothenhäusler, HB; Theokas, S; Robier, C; Mangge, H; Reicht, G; Hlade, P; Meinitzer, A.
Branched-Chain Amino Acids as New Biomarkers of Major Depression - A Novel Neurobiology of Mood Disorder.
PLoS One. 2016; 11(8):e0160542-e0160542 Doi: 10.1371/journal.pone.0160542 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Baranyi Andreas
von Lewinski Dirk
Co-Autor*innen der Med Uni Graz
Mangge Harald
Meinitzer Andreas
Robier Christoph
Rothenhäusler Hans-Bernd

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

The proteinogenic branched-chain amino acids (BCAAs) valine, leucine and isoleucine might play an unrecognised crucial role in the development of depression through their activation of the mammalian target of rapamycin (mTor) pathway. The aim of this research project is to evaluate whether BCAAs are altered in patients with major depression and might thus be appropriate biomarkers for major depression. The concentrations of valine, leucine and isoleucine were determined in 71 in-patients with major depression and 48 healthy controls by high-pressure liquid chromatography. Psychiatric and laboratory assessments were obtained at the time of in-patient admittance. The BCAAs are significantly decreased in patients with major depression in comparison with healthy subjects (valine: Mann-Whitney-U: 968.0; p <0.0001, leucine: Mann-Whitney-U: 1246.5; p = 0.013, isoleucine: Mann-Whitney-U: 1252.5; p = 0.014). Furthermore, as shown by Spearman's rank correlation coefficients, there is a significant negative correlation between valine, leucine and isoleucine concentrations and the Hamilton Depression Rating Scale (HAMD-17) as well as Beck Depression Inventory (BDI-II) scores. Our study results are strong evidence that in patients with major depression, BCAAs might be appropriate biomarkers for depression. Reduced activation of the mammalian target of rapamycin (mTor) due to a reduction of BCAAs might play a crucial unrecognised factor in the etiology of depression and may evoke depressive symptomatology and lower energy metabolism in patients with major depression. In the future, mTor and its up- and downstream signalling partners might be important targets for the development of novel antidepressants.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Amino Acids, Branched-Chain - analysis
Biomarkers - analysis
Case-Control Studies -
Chromatography, High Pressure Liquid -
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - metabolism
Depressive Disorder, Major - pathology
Down-Regulation -
Energy Metabolism -
Female -
Humans -
Isoleucine - chemistry
Isoleucine - metabolism
Leucine - chemistry
Leucine - metabolism
Male -
Middle Aged -
Mood Disorders - metabolism
Mood Disorders - pathology
Nervous System - metabolism
TOR Serine-Threonine Kinases - metabolism
Valine - chemistry
Valine - metabolism

© Med Uni Graz Impressum