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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Grübler, MR; Gaksch, M; Kienreich, K; Verheyen, N; Schmid, J; Ó, Hartaigh, B; Richtig, G; Scharnagl, H; Meinitzer, A; Fahrleitner-Pammer, A; März, W; Tomaschitz, A; Pilz, S.
Effects of vitamin D supplementation on glycated haemoglobin and fasting glucose levels in hypertensive patients: a randomized controlled trial.
Diabetes Obes Metab. 2016; 18(10):1006-12 Doi: 10.1111/dom.12709
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Führende Autor*innen der Med Uni Graz
Grübler Martin
Co-Autor*innen der Med Uni Graz
Fahrleitner-Pammer Astrid
Keppel Martin
Kienreich Katharina
März Winfried
Meinitzer Andreas
Pilz Stefan
Richtig Georg
Scharnagl Hubert
Schmid Johannes
Tomaschitz Andreas
Verheyen Nicolas Dominik

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AIM: To investigate the efficacy of vitamin D supplementation on glycaemic control. METHODS: The Styrian Vitamin D Hypertension Trial was a single-centre, double-blind, placebo-controlled study conducted between 2011 and 2014 at the Medical University of Graz, Austria. We enrolled 200 people with arterial hypertension and 25-hydroxyvitamin D [25(OH)D] concentrations <30 ng/mL. Study participants were randomized to receive either 2800 IU of vitamin D or placebo per day for 8 weeks. The present study was a post hoc analysis that incorporated an analysis of covariance (ancova) approach, while adjusting for baseline differences. RESULTS: A total of 185 participants [mean ± standard deviation age, 60.1 ± 11.3 years; 47% women; mean 25(OH)D 21.2 ± 5.6 ng/mL, mean glycated haemoglobin (HbA1c) 44.8 ± 11.8 mmol/mol and mean body mass index 30.4 ± 5.4 kg/m(2) ] completed the trial. ancova showed a mean treatment effect [95% confidence interval (CI)] on HbA1c of -3.52 (-6.7 to -0.34) mmol/mol (p = .045). There was no difference in fasting glucose -4.7 mg/dL (95% CI -16.3 to 6.9; p = .426). CONCLUSIONS: Vitamin D supplementation in obese hypertensive patients with low 25(OH)D reduces HbA1c levels. This finding warrants further investigation into potential vitamin D effects on glucose homeostasis.
Find related publications in this database (using NLM MeSH Indexing)
Aged - administration & dosage
Blood Glucose - drug effects, metabolism
Dietary Supplements - administration & dosage
Double-Blind Method - administration & dosage
Fasting - blood
Female - administration & dosage
Glycated Hemoglobin - drug effects, metabolism
Humans - administration & dosage
Hypertension - blood, complications, diet therapy
Male - administration & dosage
Middle Aged - administration & dosage
Obesity - blood, complications, diet therapy
Vitamin D - administration & dosage, analogs & derivatives, blood, pharmacology
Vitamin D Deficiency - blood, complications, diet therapy

Find related publications in this database (Keywords)
cardiovascular disease
randomised trial
type 2 diabetes
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