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SHR Neuro Krebs Kardio Lipid Stoffw Microb

De Guio, F; Jouvent, E; Biessels, GJ; Black, SE; Brayne, C; Chen, C; Cordonnier, C; De Leeuw, FE; Dichgans, M; Doubal, F; Duering, M; Dufouil, C; Duzel, E; Fazekas, F; Hachinski, V; Ikram, MA; Linn, J; Matthews, PM; Mazoyer, B; Mok, V; Norrving, B; O'Brien, JT; Pantoni, L; Ropele, S; Sachdev, P; Schmidt, R; Seshadri, S; Smith, EE; Sposato, LA; Stephan, B; Swartz, RH; Tzourio, C; van Buchem, M; van der Lugt, A; van Oostenbrugge, R; Vernooij, MW; Viswanathan, A; Werring, D; Wollenweber, F; Wardlaw, JM; Chabriat, H.
Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease.
J Cereb Blood Flow Metab. 2016; 36(8):1319-1337 Doi: 10.1177/0271678X16647396 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Co-Autor*innen der Med Uni Graz
Fazekas Franz
Ropele Stefan
Schmidt Reinhold

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Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease. © The Author(s) 2016.
Find related publications in this database (using NLM MeSH Indexing)
Biomarkers - analysis
Brain - blood supply
Brain - diagnostic imaging
Cerebral Small Vessel Diseases - diagnostic imaging
Humans -
Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Microvessels - diagnostic imaging
Reproducibility of Results -

Find related publications in this database (Keywords)
Magnetic resonance imaging
cerebral small vessel disease
brain volume
white matter hyperintensities
perivascular spaces
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