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Pilz, S; Verheyen, N; Grübler, MR; Tomaschitz, A; März, W.
Vitamin D and cardiovascular disease prevention.
Nat Rev Cardiol. 2016; 13(7):404-417 Doi: 10.1038/nrcardio.2016.73
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Führende Autor*innen der Med Uni Graz
Pilz Stefan
Co-Autor*innen der Med Uni Graz
Grübler Martin
März Winfried
Tomaschitz Andreas
Verheyen Nicolas Dominik

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Vitamin D is a precursor of the steroid hormone calcitriol that is crucial for bone and mineral metabolism. Both the high prevalence of vitamin D deficiency in the general population and the identification of the vitamin D receptor in the heart and blood vessels raised interest in the potential cardiovascular effects of vitamin D. Experimental studies have demonstrated various cardiovascular protective actions of vitamin D, but vitamin D intoxication in animals is known to induce vascular calcification. In meta-analyses of epidemiological studies, vitamin D deficiency is associated with an increased cardiovascular risk. Findings from Mendelian randomization studies and randomized, controlled trials (RCTs) do not indicate significant effects of a general vitamin D supplementation on cardiovascular outcomes. Previous RCTs, however, were not adequately designed to address extraskeletal events, and did not focus on vitamin D-deficient individuals. Therefore, currently available evidence does not support cardiovascular benefits or harms of vitamin D supplementation with the commonly used doses, and whether vitamin D has cardiovascular effects in individuals with overt vitamin D deficiency remains to be evaluated. Here, we provide an update on clinical studies on vitamin D and cardiovascular risk, discuss ongoing vitamin D research, and consider the management of vitamin D deficiency from a cardiovascular health perspective.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Blood Vessels - drug effects
Blood Vessels - metabolism
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - prevention & control
Comorbidity -
Dietary Supplements -
Humans -
Myocardium - metabolism
Nutrition Policy -
Receptors, Calcitriol - metabolism
Risk Factors -
Vitamin D - metabolism
Vitamin D - pharmacology
Vitamin D - therapeutic use
Vitamin D Deficiency - drug therapy
Vitamin D Deficiency - epidemiology

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