Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pilz, S; Verheyen, N; Grübler, MR; Tomaschitz, A; März, W.
Vitamin D and cardiovascular disease prevention.
Nat Rev Cardiol. 2016; 13(7):404-417
Doi: 10.1038/nrcardio.2016.73
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Pilz Stefan
- Co-Autor*innen der Med Uni Graz
- Grübler Martin
- März Winfried
- Tomaschitz Andreas
- Verheyen Nicolas Dominik
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- Abstract:
- Vitamin D is a precursor of the steroid hormone calcitriol that is crucial for bone and mineral metabolism. Both the high prevalence of vitamin D deficiency in the general population and the identification of the vitamin D receptor in the heart and blood vessels raised interest in the potential cardiovascular effects of vitamin D. Experimental studies have demonstrated various cardiovascular protective actions of vitamin D, but vitamin D intoxication in animals is known to induce vascular calcification. In meta-analyses of epidemiological studies, vitamin D deficiency is associated with an increased cardiovascular risk. Findings from Mendelian randomization studies and randomized, controlled trials (RCTs) do not indicate significant effects of a general vitamin D supplementation on cardiovascular outcomes. Previous RCTs, however, were not adequately designed to address extraskeletal events, and did not focus on vitamin D-deficient individuals. Therefore, currently available evidence does not support cardiovascular benefits or harms of vitamin D supplementation with the commonly used doses, and whether vitamin D has cardiovascular effects in individuals with overt vitamin D deficiency remains to be evaluated. Here, we provide an update on clinical studies on vitamin D and cardiovascular risk, discuss ongoing vitamin D research, and consider the management of vitamin D deficiency from a cardiovascular health perspective.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Vessels - drug effects
- Blood Vessels - metabolism
- Cardiovascular Diseases - epidemiology
- Cardiovascular Diseases - prevention & control
- Comorbidity -
- Dietary Supplements -
- Humans -
- Myocardium - metabolism
- Nutrition Policy -
- Receptors, Calcitriol - metabolism
- Risk Factors -
- Vitamin D - metabolism
- Vitamin D - pharmacology
- Vitamin D - therapeutic use
- Vitamin D Deficiency - drug therapy
- Vitamin D Deficiency - epidemiology