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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Pilz, S; Grübler, M; Gaksch, M; Schwetz, V; Trummer, C; Hartaigh, BÓ; Verheyen, N; Tomaschitz, A; März, W.
Vitamin D and Mortality.
Anticancer Res. 2016; 36(3):1379-87
Web of Science PubMed


Führende Autor*innen der Med Uni Graz
Pilz Stefan
Co-Autor*innen der Med Uni Graz
Grübler Martin
Keppel Martin
März Winfried
Theiler-Schwetz Verena
Tomaschitz Andreas
Trummer Christian
Verheyen Nicolas Dominik

Dimensions Citations:

Plum Analytics:
In this narrative review, we aim to summarize and discuss the current evidence linking vitamin D and mortality. Low 25-hydroxyvitamin D [25(OH)D] concentrations are associated with an increased risk of mortality. This has been shown in different cohort studies including general populations, as well as various patient cohorts. Some single-study results and meta-analyses indicate that the shape of the relationship between 25(OH)D and mortality follows a U- or a reverse J-shaped curve. Interassay and laboratory differences are, however, a limitation of most previous surveys, and standardization of 25(OH)D measurements is needed for future investigations. Apart from observational data, it has been documented in meta-analyses of randomized controlled trials that vitamin D3 supplementation is associated with a moderate, yet statistically significant, reduction in mortality. This latter finding must be interpreted in light of some limitations such as incomplete follow-up data, but such a reduction of mortality with vitamin D3 supplementation as the finding of meta-analyses of randomized controlled trials strongly argues for the benefits and, importantly, also the safety of vitamin D.
Find related publications in this database (using NLM MeSH Indexing)
Cohort Studies - administration & dosage
Dietary Supplements - administration & dosage
Humans - administration & dosage
Meta-Analysis as Topic - administration & dosage
Observational Studies as Topic - administration & dosage
Randomized Controlled Trials as Topic - administration & dosage
Vitamin D - analogs & derivatives, therapeutic use
Vitamin D Deficiency - mortality

Find related publications in this database (Keywords)
Vitamin D
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