Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pilz, S; Grübler, M; Gaksch, M; Schwetz, V; Trummer, C; Hartaigh, BÓ; Verheyen, N; Tomaschitz, A; März, W.
Vitamin D and Mortality.
Anticancer Res. 2016; 36(3):1379-87
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Pilz Stefan
- Co-Autor*innen der Med Uni Graz
- Grübler Martin
- Keppel Martin
- März Winfried
- Theiler-Schwetz Verena
- Tomaschitz Andreas
- Trummer Christian
- Verheyen Nicolas Dominik
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- In this narrative review, we aim to summarize and discuss the current evidence linking vitamin D and mortality. Low 25-hydroxyvitamin D [25(OH)D] concentrations are associated with an increased risk of mortality. This has been shown in different cohort studies including general populations, as well as various patient cohorts. Some single-study results and meta-analyses indicate that the shape of the relationship between 25(OH)D and mortality follows a U- or a reverse J-shaped curve. Interassay and laboratory differences are, however, a limitation of most previous surveys, and standardization of 25(OH)D measurements is needed for future investigations. Apart from observational data, it has been documented in meta-analyses of randomized controlled trials that vitamin D3 supplementation is associated with a moderate, yet statistically significant, reduction in mortality. This latter finding must be interpreted in light of some limitations such as incomplete follow-up data, but such a reduction of mortality with vitamin D3 supplementation as the finding of meta-analyses of randomized controlled trials strongly argues for the benefits and, importantly, also the safety of vitamin D.
- Find related publications in this database (using NLM MeSH Indexing)
- Cohort Studies - administration & dosage
- Dietary Supplements - administration & dosage
- Humans - administration & dosage
- Meta-Analysis as Topic - administration & dosage
- Observational Studies as Topic - administration & dosage
- Randomized Controlled Trials as Topic - administration & dosage
- Vitamin D - analogs & derivatives, therapeutic use
- Vitamin D Deficiency - mortality
- Find related publications in this database (Keywords)
- Vitamin D
- mortality
- RCT
- epidemiology
- 25(OH)D
- review