Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Schwarzl, M; Alogna, A; Zweiker, D; Verderber, J; Huber, S; Manninger, M; Scherr, D; Antoons, G; Pieske, BM; Post, H; Lueger, A.
A porcine model of early atrial fibrillation using a custom-built, radio transmission-controlled pacemaker.
J Electrocardiol. 2016; 49(2):124-131 Doi: 10.1016/j.jelectrocard.2015.12.012
Web of Science PubMed FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Post Heiner
Schwarzl Michael
Co-Autor*innen der Med Uni Graz
Albori Jochen
Alogna Alessio
Antoons Gudrun
Huber Sandra
Huber Stefan
Huber Stefan
Lueger Andreas
Manninger-Wünscher Martin
Pieske Burkert Mathias
Scherr Daniel
Zweiker David

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Mechanisms underlying atrial remodeling toward atrial fibrillation (AF) are incompletely understood. We induced AF in 16 pigs by 6weeks of rapid atrial pacing (RAP, 600bpm) using a custom-built, telemetrically controlled pacemaker. AF evolution was monitored three times per week telemetrically in unstressed, conscious animals. We established a dose-response relationship between RAP duration and occurrence of sustained AF >60minutes. Left atrial (LA) dilatation was present already at 2weeks of RAP. There was no evidence of left ventricular heart failure after 6weeks of RAP. As a proof-of-principle, arterial hypertension was induced in 5/16 animals by implanting desoxycorticosterone acetate (DOCA, an aldosterone-analog) subcutaneously to accelerate atrial remodeling. RAP+DOCA resulted in increased AF stability with earlier onset of sustained AF and accelerated anatomical atrial remodeling with more pronounced LA dilatation. This novel porcine model can serve to characterize effects of maladaptive stimuli or protective interventions specifically during early AF. Copyright © 2016 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Atrial Fibrillation - diagnosis
Atrial Fibrillation - physiopathology
Disease Models, Animal -
Equipment Design -
Equipment Failure Analysis -
Female -
Pacemaker, Artificial -
Prostheses and Implants -
Swine -
Telemetry - instrumentation
Telemetry - methods

Find related publications in this database (Keywords)
Atrial fibrillation
Atrial remodeling
Rapid atrial pacing
Arterial hypertension
© Med Uni Graz Impressum