Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schwarzl, M; Alogna, A; Zweiker, D; Verderber, J; Huber, S; Manninger, M; Scherr, D; Antoons, G; Pieske, BM; Post, H; Lueger, A.
A porcine model of early atrial fibrillation using a custom-built, radio transmission-controlled pacemaker.
J Electrocardiol. 2016; 49(2):124-131
Doi: 10.1016/j.jelectrocard.2015.12.012
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Post Heiner
- Schwarzl Michael
- Co-Autor*innen der Med Uni Graz
- Albori Jochen
- Alogna Alessio
- Antoons Gudrun
- Huber Sandra
- Huber Stefan
- Huber Stefan
- Lueger Andreas
- Manninger-Wünscher Martin
- Pieske Burkert Mathias
- Scherr Daniel
- Zweiker David
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- Abstract:
- Mechanisms underlying atrial remodeling toward atrial fibrillation (AF) are incompletely understood. We induced AF in 16 pigs by 6weeks of rapid atrial pacing (RAP, 600bpm) using a custom-built, telemetrically controlled pacemaker. AF evolution was monitored three times per week telemetrically in unstressed, conscious animals. We established a dose-response relationship between RAP duration and occurrence of sustained AF >60minutes. Left atrial (LA) dilatation was present already at 2weeks of RAP. There was no evidence of left ventricular heart failure after 6weeks of RAP. As a proof-of-principle, arterial hypertension was induced in 5/16 animals by implanting desoxycorticosterone acetate (DOCA, an aldosterone-analog) subcutaneously to accelerate atrial remodeling. RAP+DOCA resulted in increased AF stability with earlier onset of sustained AF and accelerated anatomical atrial remodeling with more pronounced LA dilatation. This novel porcine model can serve to characterize effects of maladaptive stimuli or protective interventions specifically during early AF. Copyright © 2016 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Atrial Fibrillation - diagnosis
- Atrial Fibrillation - physiopathology
- Disease Models, Animal -
- Equipment Design -
- Equipment Failure Analysis -
- Female -
- Pacemaker, Artificial -
- Prostheses and Implants -
- Swine -
- Telemetry - instrumentation
- Telemetry - methods
- Find related publications in this database (Keywords)
- Atrial fibrillation
- Atrial remodeling
- Rapid atrial pacing
- Porcine
- DOCA
- Arterial hypertension