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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Khalil, M; Renner, A; Langkammer, C; Enzinger, C; Ropele, S; Stojakovic, T; Scharnagl, H; Bachmaier, G; Pichler, A; Archelos, JJ; Fuchs, S; Seifert-Held, T; Fazekas, F.
Cerebrospinal fluid lipocalin 2 in patients with clinically isolated syndromes and early multiple sclerosis.
Mult Scler. 2016; 22(12):1560-1568 Doi: 10.1177/1352458515624560
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Führende Autor*innen der Med Uni Graz
Khalil Michael
Co-Autor*innen der Med Uni Graz
Archelos-Garcia Juan-Jose
Bachmaier Gerhard
Enzinger Christian
Fazekas Franz
Fuchs Siegrid
Langkammer Christian
Pichler Alexander
Ropele Stefan
Scharnagl Hubert
Seifert-Held Thomas
Stojakovic Tatjana

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Lipocalin 2 (LCN2) may be involved in the immunopathogenesis of multiple sclerosis (MS) and might further impact on iron homoeostasis. Brain iron accumulates in MS; however, the association to iron-related proteins is still unsolved. To investigate cerebrospinal fluid (CSF) and serum LCN2, transferrin (Trf) and ferritin in early MS in relation to disease evolution and longitudinal brain iron accumulation. We analysed CSF and serum LCN2 by enzyme-linked immunosorbent assay (ELISA) and Trf and ferritin by nephelometry in 55 patients (45 clinically isolated syndrome (CIS), 10 MS, median clinical follow-up 4.8 years) and 63 controls. In patients, we assessed sub-cortical grey matter iron by 3T magnetic resonance imaging (MRI) R2* relaxometry (median imaging follow-up 2.2 years). Compared to controls serum (p < 0.01), CSF (p < 0.001) LCN2 and CSF Trf (p < 0.001) levels were reduced in the patients. CSF LCN2 correlated with CSF Trf (r = 0.5, p < 0.001). In clinically stable patients, CSF LCN2 levels correlated with basal ganglia iron accumulation (r = 0.5, p < 0.05). In CIS, higher CSF LCN2 levels were associated with conversion to clinically definite MS (p < 0.05). We demonstrate altered LCN2 regulation in early MS and provide first evidence for this to be possibly linked to both clinical MS activity and iron accumulation in the basal ganglia. © The Author(s), 2016.

Find related publications in this database (Keywords)
Lipocalin 2
brain iron
multiple sclerosis
clinically isolated syndrome
cerebrospinal fluid
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