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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Katschnig-Winter, P; Koegl-Wallner, M; Pendl, T; Fazekas, F; Schwingenschuh, P.
Levodopa-responsive Holmes' Tremor Caused by a Single Inflammatory Demyelinating Lesion.
Tremor Other Hyperkinet Mov (N Y). 2015; 5(23-24):339-339 Doi: 10.7916/D8WQ033X [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Katschnig-Winter Petra
Schwingenschuh Petra
Co-Autor*innen der Med Uni Graz
Fazekas Franz

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Holmes' tremor is characterized by a combination of rest, postural, and kinetic tremor that is presumably caused by interruption of cerebello-thalamo-cortical and nigrostriatal pathways. Medical treatment remains unsatisfactory. A 16-year-old girl presented with Holmes' tremor caused by a transient midbrain abnormality on magnetic resonance imaging (MRI). To explore the discrepancy between persistent tremor and resolved MRI changes, we performed dopamine transporter single-photon emission computed tomography (DaT-SPECT) with a 123I-ioflupane that revealed nearly absent DaT binding in the right striatum. Levodopa dramatically improved the tremor. This is only the second report of a transient midbrain MRI abnormality disrupting nigrostriatal pathways. The case highlights the sometimes limited sensitivity of morphologic imaging for identifying the functional consequences of tissue damage and confirms that DaT imaging may serve as a predictor for levodopa responsiveness in Holmes' tremor.

Find related publications in this database (Keywords)
Holmes' Tremor
midbrain lesion
remitting MRI abnormalities
abnormal DaT-SPECT
Levodopa responsiveness
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