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Gattringer, T; Enzinger, C; Fischer, R; Seyfang, L; Niederkorn, K; Khalil, M; Ferrari, J; Lang, W; Brainin, M; Willeit, J; Fazekas, F.
IV thrombolysis in patients with ischemic stroke and alcohol abuse.
Neurology. 2015; 85(18):1592-1597 Doi: 10.1212/WNL.0000000000002078
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Führende Autor*innen der Med Uni Graz
Gattringer Thomas
Co-Autor*innen der Med Uni Graz
Enzinger Christian
Fazekas Franz
Fischer Renate
Khalil Michael
Niederkorn Kurt

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To determine whether chronic alcohol consumption or acute alcohol intoxication affects the rate of IV thrombolysis (IVT) and associated risk of symptomatic intracranial hemorrhage (SICH) in patients with acute ischemic stroke (IS). We analyzed data from the nationwide Austrian Stroke Unit Registry for all patients with IS admitted to one of 35 stroke units between 2004 and 2014. We compared demographic and clinical characteristics for patients with chronic alcohol consumption (>2 drinks/d) or acute intoxication and for patients without these factors and their rates of IVT and associated SICH. We identified 47,422 patients with IS. Of these patients, 3,999 (8.5%) consumed alcohol chronically and 216 (0.5%) presented with acute intoxication. Alcohol abusers were younger, more frequently men, and less often functionally disabled before the index event. Stroke severity was comparable between alcoholic and nonalcoholic IS patients. Nevertheless, patients who abused alcohol were less likely to receive IVT (16.6% vs 18.9%) and this difference remained after accounting for possible confounders. Rates of SICH after IVT were not increased in patients who abused alcohol (2.1% vs 3.7%, p = 0.04). Multivariate analysis including age, NIH Stroke Scale score, and time from symptom onset to IVT treatment showed that alcohol abuse was not an independent risk factor for SICH and was not protective (odds ratio 0.73, 95% confidence interval 0.43-1.25, p = 0.2). IS patients with chronic alcohol consumption or acute intoxication have decreased likelihood of receiving IVT and are not at an increased risk of associated SICH. This supports current practice guidelines, which do not list chronic alcohol consumption or acute intoxication as an exclusion criterion. © 2015 American Academy of Neurology.
Find related publications in this database (using NLM MeSH Indexing)
Administration, Intravenous -
Aged -
Aged, 80 and over -
Alcoholic Intoxication - complications
Alcoholism - complications
Alcoholism -
Brain Ischemia - complications
Brain Ischemia - drug therapy
Cohort Studies -
Female -
Humans -
Intracranial Hemorrhages - chemically induced
Male -
Middle Aged -
Odds Ratio -
Prospective Studies -
Registries -
Severity of Illness Index -
Stroke - complications
Stroke - drug therapy
Thrombolytic Therapy - adverse effects
Time-to-Treatment -
Treatment Outcome -

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