Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Aigner, B; Bauernhofer, T; Petru, E; Niederkorn, A; Arzberger, EJ; Richtig, E.
Complete recovery of a wide local reaction by the use of dexrazoxane 72 hours after epirubicin extravasation: case report and review of the literature.
Dermatology. 2014; 229(4):288-292 Doi: 10.1159/000365391 (- Case Report)
Web of Science PubMed FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Richtig Erika
Sadoghi Birgit
Co-Autor*innen der Med Uni Graz
Arzberger Edith Johanna
Bauernhofer Thomas
Petru Edgar
Schiefer-Niederkorn Anna

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Accidental extravasation of anthracyclines might result in devastating side effects and complications, including necrosis of tissue, with impairment of neighboring structures - most of them requiring surgery. Following recent approach guidelines, intravenous administration of dexrazoxane within 6 h after the event is recommended. We report on a 63-year-old female patient with breast cancer treated with epirubicin combination therapy. She experienced extravasation on the distal right arm at the end of the very first cycle, being initially treated with dimethylsulfoxide 99% topically. Clinical symptoms became worse. Despite the interval between the event and referral, dexrazoxane was given once daily for 3 days. She recovered completely without any sequelae. To our knowledge, this is the first case report of a successful treatment and complete recovery by the use of dexrazoxane even 3 days after extensive epirubicin extravasation. Additionally, a review of the literature is given.
Find related publications in this database (using NLM MeSH Indexing)
Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast Neoplasms - drug therapy
Cyclophosphamide - administration & dosage
Dexrazoxane - administration & dosage
Dimethyl Sulfoxide - therapeutic use
Drug Eruptions - drug therapy Drug Eruptions - etiology
Epirubicin - administration & dosage Epirubicin - adverse effects
Extravasation of Diagnostic and Therapeutic Materials - complications
Female -
Fluorouracil - administration & dosage
Free Radical Scavengers - therapeutic use
Humans -
Middle Aged -
Time Factors -
Topoisomerase II Inhibitors - administration & dosage

Find related publications in this database (Keywords)
Adverse event
© Med Uni Graz Impressum