Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Aigner, B; Bauernhofer, T; Petru, E; Niederkorn, A; Arzberger, EJ; Richtig, E.
Complete recovery of a wide local reaction by the use of dexrazoxane 72 hours after epirubicin extravasation: case report and review of the literature.
Dermatology. 2014; 229(4):288-292
Doi: 10.1159/000365391
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Richtig Erika
- Sadoghi Birgit
- Co-Autor*innen der Med Uni Graz
- Arzberger Edith Johanna
- Bauernhofer Thomas
- Petru Edgar
- Schiefer-Niederkorn Anna
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- Abstract:
- Accidental extravasation of anthracyclines might result in devastating side effects and complications, including necrosis of tissue, with impairment of neighboring structures - most of them requiring surgery. Following recent approach guidelines, intravenous administration of dexrazoxane within 6 h after the event is recommended. We report on a 63-year-old female patient with breast cancer treated with epirubicin combination therapy. She experienced extravasation on the distal right arm at the end of the very first cycle, being initially treated with dimethylsulfoxide 99% topically. Clinical symptoms became worse. Despite the interval between the event and referral, dexrazoxane was given once daily for 3 days. She recovered completely without any sequelae. To our knowledge, this is the first case report of a successful treatment and complete recovery by the use of dexrazoxane even 3 days after extensive epirubicin extravasation. Additionally, a review of the literature is given.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Breast Neoplasms - drug therapy
- Cyclophosphamide - administration & dosage
- Dexrazoxane - administration & dosage
- Dimethyl Sulfoxide - therapeutic use
- Drug Eruptions - drug therapy Drug Eruptions - etiology
- Epirubicin - administration & dosage Epirubicin - adverse effects
- Extravasation of Diagnostic and Therapeutic Materials - complications
- Female -
- Fluorouracil - administration & dosage
- Free Radical Scavengers - therapeutic use
- Humans -
- Middle Aged -
- Time Factors -
- Topoisomerase II Inhibitors - administration & dosage
- Find related publications in this database (Keywords)
- Dexrazoxane
- Chemotherapeutics
- Extravasation
- Adverse event
- Epirubicin