Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Seiler, S; Pirpamer, L; Hofer, E; Duering, M; Jouvent, E; Fazekas, F; Mangin, JF; Chabriat, H; Dichgans, M; Ropele, S; Schmidt, R.
Magnetization transfer ratio relates to cognitive impairment in normal elderly.
Front Aging Neurosci. 2014; 6(2):263-263 Doi: 10.3389/fnagi.2014.00263 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Führende Autor*innen der Med Uni Graz: Schmidt Reinhold; Seiler Stephan
Co-Autor*innen der Med Uni Graz: Fazekas Franz; Hofer Edith; Pirpamer Lukas; Ropele Stefan
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Abstract:: Magnetization transfer imaging (MTI) can detect microstructural brain tissue changes and may be helpful in determining age-related cerebral damage. We investigated the association between the magnetization transfer ratio (MTR) in gray and white matter (WM) and cognitive functioning in 355 participants of the Austrian stroke prevention family study (ASPS-Fam) aged 38-86 years. MTR maps were generated for the neocortex, deep gray matter structures, WM hyperintensities, and normal appearing WM (NAWM). Adjusted mixed models determined whole brain and lobar cortical MTR to be directly and significantly related to performance on tests of memory, executive function, and motor skills. There existed an almost linear dose-effect relationship. MTR of deep gray matter structures and NAWM correlated to executive functioning. All associations were independent of demographics, vascular risk factors, focal brain lesions, and cortex volume. Further research is needed to understand the basis of this association at the tissue level, and to determine the role of MTR in predicting cognitive decline and dementia.
Find related publications in this database (Keywords): cerebrovascular disease; dementia; cognitive aging; magnetic resonance imaging; magnetization transfer imaging; microstructural tissue damage