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Friesenbichler, J; Sadoghi, P; Maurer-Ertl, W; Szkandera, J; Glehr, M; Ogris, K; Wolf, M; Weger, C; Leithner, A.
Serum metal ion concentrations in paediatric patients following total knee arthroplasty using megaprostheses.
Biomed Res Int. 2014; 2014(6):817257-817257 Doi: 10.1155/2014/817257 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Friesenbichler Jörg
Sadoghi Patrick
Co-Autor*innen der Med Uni Graz
Glehr Mathias
Leithner Andreas
Maurer-Ertl Werner
Ogris Kathrin
Szkandera Joanna
Weger Christian
Wolf Matthias

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The purpose of this study was to determine the concentrations of cobalt, chromium, and molybdenum in the serum of paediatric tumour patients after fixed hinge total knee arthroplasty. Further, these metal ion levels were compared with serum metal ion levels of patients with other orthopaedic devices such as hip and knee prostheses with metal-on-metal or metal-on-polyethylene articulation to find differences between anatomical locations, abrasion characteristics, and bearing surfaces. After an average follow-up of 108 months (range: 67 to 163) of 11 paediatric patients with fixed hinge total knee arthroplasty, the mean concentrations for Co and Cr were significantly increased while Mo was within the limits compared to the upper values from the reference laboratory. Furthermore, these serum concentrations were significantly higher compared to patients with a standard rotating hinge device (P = 0.002 and P < 0.001) and preoperative controls (P < 0.001). On the other hand, the serum levels of patients following MoM THA or rotating hinge arthroplasty using megaprostheses were higher. Therefore, periodic long-term follow-ups are recommended due to the rising concerns about systemic metal ion exposure in the literature. Upon the occurrence of adverse reactions to metal debris the revision of the fixed hinge implant should be considered.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Arthroplasty, Replacement, Knee -
Case-Control Studies -
Child -
Demography -
Female -
Hip Prosthesis -
Humans -
Ions - blood
Male -
Metals - blood

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