Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stotz, M; Szkandera, J; Seidel, J; Stojakovic, T; Samonigg, H; Reitz, D; Gary, T; Kornprat, P; Schaberl-Moser, R; Hoefler, G; Gerger, A; Pichler, M.
Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients.
PLoS One. 2014; 9(8):e104730-e104730
Doi: 10.1371/journal.pone.0104730
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- Führende Autor*innen der Med Uni Graz
- Stotz Michael
- Co-Autor*innen der Med Uni Graz
- Gary Thomas
- Gerger Armin
- Höfler Gerald
- Kornprat Peter
- Pichler Martin
- Samonigg Hellmut
- Schaberl-Moser Renate
- Seidel Julia
- Stojakovic Tatjana
- Szkandera Joanna
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- Abstract:
- Recently, chemical blood parameters gain more attraction as potential prognostic parameters in pancreatic cancer (PC). In the present study we investigated the prognostic relevance of the uric acid (UA) level in blood plasma at the time of diagnosis for overall survival (OS) in a large cohort of patients with PC. Data from 466 consecutive patients with ductal adenocarcinoma of the pancreas were evaluated retrospectively. Overall survival (OS) was analysed using the Kaplan-Meier method. To further evaluate the prognostic significance of the UA level, univariate and multivariate Cox regression models were calculated. None of the clinicopathological parameters (tumour grade, clinical stage, age, CA19-9 level, Karnofski Index (KI) or surgical resection) except gender was associated with UA level. In univariate analysis we observed the elevated UA level (<5.1 versus ≥5.1 mg/dl, p = 0.017) as poor prognostic factor for OS. In the multivariate analysis that included age, gender, tumour grade, tumour stage, surgical resection, CA19-9 level, the KI and UA level we confirmed the UA level as independent prognostic factor for OS (HR = 1.373%; CI = 1.077-1.751; p = 0.011). In conclusion, we identified the UA level at time of diagnosis as an independent prognostic factor in PC patients. Our results indicate that the UA level might represent a novel and useful marker for patient stratification in PC management.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biomarkers, Tumor - blood
- Carcinoma, Pancreatic Ductal - blood
- Cohort Studies -
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Male -
- Middle Aged -
- Multivariate Analysis -
- Pancreatic Neoplasms - blood
- Prognosis -
- Proportional Hazards Models -
- Uric Acid - blood