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Hutterer, GC; Stoeckigt, C; Stojakovic, T; Jesche, J; Eberhard, K; Pummer, K; Zigeuner, R; Pichler, M.
Low preoperative lymphocyte-monocyte ratio (LMR) represents a potentially poor prognostic factor in nonmetastatic clear cell renal cell carcinoma.
Urol Oncol. 2014; 32(7):1041-1048 Doi: 10.1016/j.urolonc.2014.04.001
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Führende Autor*innen der Med Uni Graz
Hutterer Georg
Co-Autor*innen der Med Uni Graz
Eberhard Katharina
Jesche-Chromecki Johanna
Pichler Martin
Pummer Karl
Stojakovic Tatjana
Zigeuner Richard

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To explore the potential prognostic significance of the lymphocyte-monocyte ratio (LMR) in patients with nonmetastatic renal cell carcinoma (RCC), as the LMR has been repeatedly proposed to have a negative effect on patient׳s survival in various hematological and solid cancers. However, findings about LMR׳s prognostic significance in RCC have not been reported yet. We retrospectively evaluated the prognostic significance of the LMR in a cohort comprising 678 patients with nonmetastatic clear cell RCC, who were operated between 2000 and 2010 with curative radical or partial nephrectomy at a single tertiary academic center. Preoperative LMR was calculated 1 day before surgical intervention. Patients were categorized using an LMR cutoff of 3.0. Cancer-specific survival (CSS), metastasis-free survival, and overall survival were assessed using the Kaplan-Meier method. To evaluate the independent prognostic significance of the LMR, multivariate Cox regression models were applied. Additionally, the influence of the LMR on the predictive accuracy of the Leibovich prognosis score was determined using the Harrell concordance index (c-index) and decision curve analysis. Low LMR was statistically significantly associated with older patients (≥65 y), high tumor grade (G3+G4), advanced pathologic T category (pT3+pT4), the presence of histologic tumor necrosis, and male gender (P<0.05). Multivariate analysis identified a low LMR as an independent prognostic factor for patients׳ CSS (hazard ratio = 2.33; 95% CI: 1.10-4.94; P = 0.027). The estimated c-index was 0.83 using the Leibovich prognosis score and 0.86 when the LMR was added. Regarding CSS of patients with RCC, a decreased LMR represents an independent prognostic factor. Adding the LMR to well-established prognostic models, such as the Leibovich prognosis score, might improve their predictive ability. Copyright © 2014 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Carcinoma, Renal Cell - immunology
Carcinoma, Renal Cell - mortality
Carcinoma, Renal Cell - pathology
Female -
Humans -
Kaplan-Meier Estimate -
Kidney Neoplasms - immunology
Kidney Neoplasms - mortality
Kidney Neoplasms - pathology
Lymphocyte Count -
Lymphocytes -
Male -
Middle Aged -
Monocytes -
Prognosis -
Proportional Hazards Models -
Retrospective Studies -
Young Adult -

Find related publications in this database (Keywords)
Renal cell carcinoma
Validation study
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