Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lindenmann, J; Fink-Neuboeck, N; Koesslbacher, M; Pichler, M; Stojakovic, T; Roller, RE; Maier, A; Anegg, U; Smolle, J; Smolle-Juettner, FM.
The influence of elevated levels of C-reactive protein and hypoalbuminemia on survival in patients with advanced inoperable esophageal cancer undergoing palliative treatment.
J Surg Oncol. 2014; 110(6):645-650
Doi: 10.1002/jso.23711
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Lindenmann Jörg
- Co-Autor*innen der Med Uni Graz
- Anegg Udo
- Maier Alfred
- Pichler Martin
- Roller-Wirnsberger Regina
- Smolle Josef
- Smolle-Juettner Freyja-Maria
- Stojakovic Tatjana
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- Abstract:
- Inflammation perpetuates individual tumor progression resulting in decreased survival in cancer patients. The aim of our study was to evaluate the influence of elevated levels of C-reactive protein (CRP) as well as low levels of albumin on patients with inoperable esophageal carcinoma. The data of 218 patients with advanced esophageal cancer, who were treated at a single center within 12 years, were evaluated retrospectively. Patient's age, gender, body weight, dysphagia, plasma levels of CRP and albumin, the Glasgow Prognostic Score (GPS) combining both indicators, and survival were assessed for statistical evaluation. Thirty-nine (18.2%) had hypoalbuminemia and 161 (73.9%) had elevated CRP levels. Patients with hypoalbuminemia (P = 0.001) as well as patients with increased CRP levels (P = 0.001) showed a significantly shorter survival. Weight loss was correlated to elevated plasma CRP (P = 0.022), to diarrhea (P = 0.021), and to dysphagia (P = 0.008). Increasing GPS was significantly associated with poor survival (P = 0.001). Elevated CRP levels and hypoalbuminemia are significantly associated with reduced survival and are considered to be an appropriate predictor for poor outcome in advanced esophageal carcinoma. The GPS provides additional detailed prognostication and should be therefore taken into consideration when the individual palliative strategy has to be scheduled. © 2014 Wiley Periodicals, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - blood Adenocarcinoma - mortality Adenocarcinoma - therapy
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers, Tumor - blood
- C-Reactive Protein - analysis
- Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - therapy
- Deglutition Disorders - etiology
- Diarrhea - etiology
- Esophageal Neoplasms - blood Esophageal Neoplasms - mortality Esophageal Neoplasms - therapy
- Female -
- Humans -
- Hypoalbuminemia - blood
- Kaplan-Meier Estimate -
- Male -
- Middle Aged -
- Palliative Care -
- Prognosis -
- Retrospective Studies -
- Weight Loss -
- Young Adult -
- Find related publications in this database (Keywords)
- esophageal carcinoma
- advanced cancer
- C-reactive protein
- hypoalbuminemia
- survival