Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Al-Zoughbi, W; Al-Zhoughbi, W; Huang, J; Paramasivan, GS; Till, H; Pichler, M; Guertl-Lackner, B; Hoefler, G.
Tumor macroenvironment and metabolism.
Semin Oncol. 2014; 41(2):281-295
Doi: 10.1053/j.seminoncol.2014.02.005
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Höfler Gerald
- Huang Jianfeng
- Co-Autor*innen der Med Uni Graz
- Al-Zoughbi Wael
- Gürtl-Lackner Barbara
- Paramasivan Ganapathy Shanmugam
- Pichler Martin
- Till Holger
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- Abstract:
- In this review we introduce the concept of the tumor macroenvironment and explore it in the context of metabolism. Tumor cells interact with the tumor microenvironment including immune cells. Blood and lymph vessels are the critical components that deliver nutrients to the tumor and also connect the tumor to the macroenvironment. Several factors are then released from the tumor itself but potentially also from the tumor microenvironment, influencing the metabolism of distant tissues and organs. Amino acids, and distinct lipid and lipoprotein species can be essential for further tumor growth. The role of glucose in tumor metabolism has been studied extensively. Cancer-associated cachexia is the most important tumor-associated systemic syndrome and not only affects the quality of life of patients with various malignancies but is estimated to be the cause of death in 15%-20% of all cancer patients. On the other hand, systemic metabolic diseases such as obesity and diabetes are known to influence tumor development. Furthermore, the clinical implications of the tumor macroenvironment are explored in the context of the patient's outcome with special consideration for pediatric tumors. Finally, ways to target the tumor macroenvironment that will provide new approaches for therapeutic concepts are described. Copyright © 2014 Elsevier Inc. All rights reserved.
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