Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Loitfelder, M; Fazekas, F; Koschutnig, K; Fuchs, S; Petrovic, K; Ropele, S; Pichler, A; Jehna, M; Langkammer, C; Schmidt, R; Neuper, C; Enzinger, C.
Brain activity changes in cognitive networks in relapsing-remitting multiple sclerosis - insights from a longitudinal FMRI study.
PLoS One. 2014; 9(4):e93715-e93715 Doi: 10.1371/journal.pone.0093715 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Enzinger Christian
Koini Marisa
Co-Autor*innen der Med Uni Graz
Fazekas Franz
Fuchs Siegrid
Jehna Margit
Koschutnig Karl
Langkammer Christian
Petrovic Katja-Elisabeth
Pichler Alexander
Ropele Stefan
Schmidt Reinhold

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Extrapolations from previous cross-sectional fMRI studies suggest cerebral functional changes with progression of Multiple Sclerosis (MS), but longitudinal studies are scarce. We assessed brain activation changes over time in MS patients using a cognitive fMRI paradigm and examined correlations with clinical and cognitive status and brain morphology. 13 MS patients and 15 healthy controls (HC) underwent MRI including fMRI (go/no-go task), neurological and neuropsychological exams at baseline (BL) and follow-up (FU; minimum 12, median 20 months). We assessed estimates of and changes in fMRI activation, total brain and subcortical grey matter volumes, cortical thickness, and T2-lesion load. Bland-Altman (BA) plots served to assess fMRI signal variability. Cognitive and disability levels remained largely stable in the patients. With the fMRI task, both at BL and FU, patients compared to HC showed increased activation in the insular cortex, precuneus, cerebellum, posterior cingulate cortex, and occipital cortex. At BL, patients vs. HC also had lower caudate nucleus, thalamus and putamen volumes. Over time, patients (but not HC) demonstrated fMRI activity increments in the left inferior parietal lobule. These correlated with worse single-digit-modality test (SDMT) performance. BA-plots attested to reproducibility of the fMRI task. In the patients, the right caudate nucleus decreased in volume which again correlated with worsening SDMT performance. Given preserved cognitive performance, the increased activation at BL in the patients may be viewed as largely adaptive. In contrast, the negative correlation with SDMT performance suggests increasing parietal activation over time to be maladaptive. Several areas with purported relevance for cognition showed decreased volumes at BL and right caudate nucleus volume decline correlated with decreasing SDMT performance. This highlights the dynamics of functional changes and the strategic importance of specific brain areas for cognitive processes in MS.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Brain - physiopathology
Brain Mapping -
Case-Control Studies -
Cluster Analysis -
Cognition - physiology
Female -
Follow-Up Studies -
Gray Matter - physiopathology
Humans -
Longitudinal Studies -
Magnetic Resonance Imaging -
Male -
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Nerve Net - physiopathology
Neuropsychological Tests -
Task Performance and Analysis -
Time Factors -

© Med Uni Graz Impressum