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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Ropele, S; Wattjes, MP; Langkammer, C; Kilsdonk, ID; Graaf, WL; Frederiksen, JL; Fuglø, D; Yiannakas, M; Wheeler-Kingshott, CA; Enzinger, C; Rocca, MA; Sprenger, T; Amman, M; Kappos, L; Filippi, M; Rovira, A; Ciccarelli, O; Barkhof, F; Fazekas, F.
Multicenter R2* mapping in the healthy brain.
Magn Reson Med. 2014; 71(3):1103-1107 Doi: 10.1002/mrm.24772
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Führende Autor*innen der Med Uni Graz
Ropele Stefan
Co-Autor*innen der Med Uni Graz
Enzinger Christian
Fazekas Franz
Langkammer Christian

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The R2* relaxation rate constant has been suggested as a sensitive measure for iron accumulation. The aim of this multi-center study was to assess the inter-scanner and inter-subject variability of R2* mapping and to investigate the relationship between brain volume and R2* in specific structures. R2* mapping was performed in 81 healthy subjects in seven centers using different 3 T systems. R2* was calculated from a dual-echo gradient echo sequence and was assessed in several deep gray matter structures. The inter-scanner and inter-subject variability of R2* was calculated by means of the coefficient of variation before and after correcting for age. Significant center effects were seen in some regions which get lost after age correction. The coefficient of variation for the inter-center variability was much lower (<5.6%) than for the intra-subject variability (6.7%-11.7%). R2* in the putamen and red nucleus scaled with cortical volume while R2* in the globus pallidus and the substantia nigra was negatively associated with white matter volume. R2* is a robust and reproducible measure in a multicenter setting provided that a standardized MRI protocol is used. The relationship between iron concentration in deep gray matter and volume of specific brain compartments needs further investigation. Copyright © 2013 Wiley Periodicals, Inc.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Brain - anatomy & histology
Brain -
Female -
Gray Matter - anatomy & histology
Humans -
Image Interpretation, Computer-Assisted - methods
Imaging, Three-Dimensional - methods
Magnetic Resonance Imaging - methods
Male -
Middle Aged -
Organ Size -
Reference Values -
Reproducibility of Results -
Sensitivity and Specificity -
White Matter - anatomy & histology
Young Adult -

Find related publications in this database (Keywords)
deep gray matter
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