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Dalpiaz, O; Pichler, M; Mannweiler, S; Martín Hernández, JM; Stojakovic, T; Pummer, K; Zigeuner, R; Hutterer, GC.
Validation of the pretreatment derived neutrophil-lymphocyte ratio as a prognostic factor in a European cohort of patients with upper tract urothelial carcinoma.
Br J Cancer. 2014; 110(10):2531-2536 Doi: 10.1038/bjc.2014.180 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Dalpiaz Orietta
Pichler Martin
Co-Autor*innen der Med Uni Graz
Hutterer Georg
Mannweiler Sebastian
Martin Hernandez Jessica Maria
Pummer Karl
Stojakovic Tatjana
Zigeuner Richard

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The value of a combined index of neutrophil and white cell counts, named derived neutrophil-lymphocyte ratio (dNLR), has recently been proposed as a prognosticator of survival in various cancer types. We investigated the prognostic role of the dNLR in a large European cohort of patients with upper tract urothelial carcinoma (UTUC). Data from 171 non-metastatic UTUC patients, operated between 1990 and 2012 at a single tertiary academic centre, were evaluated retrospectively. Cancer-specific- (CSS) as well as overall survival (OS) were assessed using the Kaplan-Meier method. To evaluate the independent prognostic significance of the dNLR, multivariate proportional Cox-regression models were applied. Additionally, the influence of the dNLR on the predictive accuracy of the multivariate model was further determined by Harrell's concordance index (c-index). The median follow-up period was 31 months. An increased dNLR was statistically significantly associated with shorter CSS (log-rank P=0.004), as well as with shorter OS (log-rank P=0.002). Multivariate analysis identified dNLR as an independent predictor for CSS (hazard ratio, HR=1.16, 95% confidence interval, CI=1.01-1.35, P=0.045), as well as for OS (HR=1.21, 95% CI=1.09-1.34, P<0.001). The estimated c-index of the multivariate model for OS was 0.68 without dNLR and 0.73 when dNLR was added. Patients with a high pretreatment dNLR could be predicted to show subsequently higher cancer-specific- as well as overall mortality after surgery for UTUC compared with those with a low pretreatment dNLR. Thus, this combined index should be considered as a potential prognostic biomarker in future.
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Aged -
Aged - epidemiology
Carcinoma, Transitional Cell - blood
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Confounding Factors (Epidemiology) -
Female -
Follow-Up Studies -
Humans -
Kaplan-Meier Estimate -
Kidney Neoplasms - blood
Kidney Neoplasms - mortality
Kidney Neoplasms - surgery
Leukocyte Count -
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Necrosis -
Neutrophils -
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Proportional Hazards Models -
ROC Curve -
Retrospective Studies -
Ureteral Neoplasms - blood
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Ureteral Neoplasms - surgery

Find related publications in this database (Keywords)
derived neutrophil-lymphocyte ratio
upper tract urothelial carcinoma
validation study
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