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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Birngruber, T; Ghosh, A; Hochmeister, S; Asslaber, M; Kroath, T; Pieber, TR; Sinner, F.
Long-term implanted cOFM probe causes minimal tissue reaction in the brain.
PLoS One. 2014; 9(3):e90221-e90221 Doi: 10.1371/journal.pone.0090221 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Birngruber Thomas
Ghosh Arijit
Sinner Frank Michael
Co-Autor*innen der Med Uni Graz
Asslaber Martin
Hochmeister Sonja
Pieber Thomas

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This study investigated the histological tissue reaction to long-term implanted cerebral open flow microperfusion (cOFM) probes in the frontal lobe of the rat brain. Most probe-based cerebral fluid sampling techniques are limited in application time due to the formation of a glial scar that hinders substance exchange between brain tissue and the probe. A glial scar not only functions as a diffusion barrier but also alters metabolism and signaling in extracellular brain fluid. cOFM is a recently developed probe-based technique to continuously sample extracellular brain fluid with an intact blood-brain barrier. After probe implantation, a 2 week healing period is needed for blood-brain barrier reestablishment. Therefore, cOFM probes need to stay in place and functional for at least 15 days after implantation to ensure functionality. Probe design and probe materials are optimized to evoke minimal tissue reaction even after a long implantation period. Qualitative and quantitative histological tissue analysis revealed no continuous glial scar formation around the cOFM probe 30 days after implantation and only a minor tissue reaction regardless of perfusion of the probe.
Find related publications in this database (using NLM MeSH Indexing)
Animals -
Blood-Brain Barrier - cytology
Blood-Brain Barrier - metabolism
Brain - cytology
Brain - metabolism
Calcium-Binding Proteins - metabolism
Electrodes, Implanted - adverse effects
Frontal Lobe - cytology
Frontal Lobe - metabolism
Glial Fibrillary Acidic Protein -
Male -
Microfilament Proteins - metabolism
Nerve Tissue Proteins - metabolism
Perfusion - instrumentation
Prosthesis Design -
Rats -
Rats, Sprague-Dawley -
Time Factors -

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