Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Birngruber, T; Ghosh, A; Hochmeister, S; Asslaber, M; Kroath, T; Pieber, TR; Sinner, F.
Long-term implanted cOFM probe causes minimal tissue reaction in the brain.
PLoS One. 2014; 9(3):e90221-e90221
Doi: 10.1371/journal.pone.0090221
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- Führende Autor*innen der Med Uni Graz
- Birngruber Thomas
- Ghosh Arijit
- Sinner Frank Michael
- Co-Autor*innen der Med Uni Graz
- Asslaber Martin
- Hochmeister Sonja
- Pieber Thomas
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- Abstract:
- This study investigated the histological tissue reaction to long-term implanted cerebral open flow microperfusion (cOFM) probes in the frontal lobe of the rat brain. Most probe-based cerebral fluid sampling techniques are limited in application time due to the formation of a glial scar that hinders substance exchange between brain tissue and the probe. A glial scar not only functions as a diffusion barrier but also alters metabolism and signaling in extracellular brain fluid. cOFM is a recently developed probe-based technique to continuously sample extracellular brain fluid with an intact blood-brain barrier. After probe implantation, a 2 week healing period is needed for blood-brain barrier reestablishment. Therefore, cOFM probes need to stay in place and functional for at least 15 days after implantation to ensure functionality. Probe design and probe materials are optimized to evoke minimal tissue reaction even after a long implantation period. Qualitative and quantitative histological tissue analysis revealed no continuous glial scar formation around the cOFM probe 30 days after implantation and only a minor tissue reaction regardless of perfusion of the probe.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood-Brain Barrier - cytology
- Blood-Brain Barrier - metabolism
- Brain - cytology
- Brain - metabolism
- Calcium-Binding Proteins - metabolism
- Electrodes, Implanted - adverse effects
- Frontal Lobe - cytology
- Frontal Lobe - metabolism
- Glial Fibrillary Acidic Protein -
- Male -
- Microfilament Proteins - metabolism
- Nerve Tissue Proteins - metabolism
- Perfusion - instrumentation
- Prosthesis Design -
- Rats -
- Rats, Sprague-Dawley -
- Time Factors -