Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Williams, SK; Maier, O; Fischer, R; Fairless, R; Hochmeister, S; Stojic, A; Pick, L; Haar, D; Musiol, S; Storch, MK; Pfizenmaier, K; Diem, R.
Antibody-mediated inhibition of TNFR1 attenuates disease in a mouse model of multiple sclerosis.
PLoS One. 2014; 9(2):e90117-e90117
Doi: 10.1371/journal.pone.0090117
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- Co-Autor*innen der Med Uni Graz
- Hochmeister Sonja
- Storch Maria
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- Abstract:
- Tumour necrosis factor (TNF) is a proinflammatory cytokine that is known to regulate inflammation in a number of autoimmune diseases, including multiple sclerosis (MS). Although targeting of TNF in models of MS has been successful, the pathological role of TNF in MS remains unclear due to clinical trials where the non-selective inhibition of TNF resulted in exacerbated disease. Subsequent experiments have indicated that this may have resulted from the divergent effects of the two TNF receptors, TNFR1 and TNFR2. Here we show that the selective targeting of TNFR1 with an antagonistic antibody ameliorates symptoms of the most common animal model of MS, experimental autoimmune encephalomyelitis (EAE), when given following both a prophylactic and therapeutic treatment regime. Our results demonstrate that antagonistic TNFR1-specific antibodies may represent a therapeutic approach for the treatment of MS in the future.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antibodies - pharmacology
- Disease Models, Animal -
- Encephalomyelitis, Autoimmune, Experimental - genetics
- Encephalomyelitis, Autoimmune, Experimental - immunology
- Encephalomyelitis, Autoimmune, Experimental - pathology
- Encephalomyelitis, Autoimmune, Experimental - therapy
- Female -
- Gene Expression -
- Immunotherapy -
- Mice -
- Mice, Inbred C57BL -
- Mice, Knockout -
- Molecular Targeted Therapy -
- Multiple Sclerosis - genetics
- Multiple Sclerosis - immunology
- Multiple Sclerosis - pathology
- Multiple Sclerosis - therapy
- Receptors, Tumor Necrosis Factor, Type I - antagonists & inhibitors
- Receptors, Tumor Necrosis Factor, Type I - deficiency
- Receptors, Tumor Necrosis Factor, Type I - genetics
- Receptors, Tumor Necrosis Factor, Type II - antagonists & inhibitors
- Receptors, Tumor Necrosis Factor, Type II - deficiency
- Receptors, Tumor Necrosis Factor, Type II - genetics