Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Szkandera, J; Pichler, M; Absenger, G; Stotz, M; Arminger, F; Weissmueller, M; Schaberl-Moser, R; Samonigg, H; Kornprat, P; Stojakovic, T; Avian, A; Gerger, A.
The elevated preoperative platelet to lymphocyte ratio predicts decreased time to recurrence in colon cancer patients.
Am J Surg. 2014; 208(2):210-214
Doi: 10.1016/j.amjsurg.2013.10.030
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Gerger Armin
- Szkandera Joanna
- Co-Autor*innen der Med Uni Graz
- Absenger Gudrun
- Avian Alexander
- Kornprat Peter
- Pichler Martin
- Samonigg Hellmut
- Schaberl-Moser Renate
- Stojakovic Tatjana
- Stotz Michael
- Weissmüller Melanie
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- Abstract:
- Recent evidence indicates that tumor progression involves factors of systemic inflammation, such as platelets and lymphocytes. In this study, we investigated the prognostic relevance of the preoperative platelet to lymphocyte (P/L) ratio on time to recurrence (TTR) and overall survival (OS) in patients with stage II and III colon cancer (CC) who underwent curative resection. In this retrospective study, 372 CC patients were included. Kaplan-Meier curves and multivariate Cox proportional models were calculated for TTR and OS. In univariate analysis, the elevated P/L ratio was significantly associated with decreased TTR (HR = 1.60, 95% CI = 1.02 to 2.51, P = .040) and remained significant in multivariate analysis (HR = 1.65, 95% CI = 1.05 to 2.58, P = .030), where HR and CI represent Hazard ratio and confidence interval, respectively. Patients with elevated P/L ratio showed a median TTR of 116 months. In contrast, patients with low P/L ratio had a median TTR of 132 months. In OS analysis, the elevated P/L ratio showed a trend toward decreased OS in univariate analysis (HR = 1.54, 95% CI = .95 to 2.48, P = .079). In this study, we identified the preoperative P/L ratio as a prognostic marker for TTR in stage II and III CC patients. Copyright © 2014 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Colonic Neoplasms - blood Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colonic Neoplasms - surgery
- Female -
- Humans -
- Lymphocyte Count -
- Male -
- Middle Aged -
- Multivariate Analysis -
- Neoplasm Recurrence, Local - blood
- Platelet Count -
- Preoperative Period -
- Prognosis -
- Retrospective Studies -
- Time Factors -
- Find related publications in this database (Keywords)
- Platelet to lymphocyte ratio
- Systemic inflammation
- Colon cancer
- Prognostic factor