Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Szkandera, J; Pichler, M; Absenger, G; Stotz, M; Arminger, F; Weissmueller, M; Schaberl-Moser, R; Samonigg, H; Kornprat, P; Stojakovic, T; Avian, A; Gerger, A.
The elevated preoperative platelet to lymphocyte ratio predicts decreased time to recurrence in colon cancer patients.
Am J Surg. 2014; 208(2):210-214 Doi: 10.1016/j.amjsurg.2013.10.030
Web of Science PubMed FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Gerger Armin
Szkandera Joanna
Co-Autor*innen der Med Uni Graz
Absenger Gudrun
Avian Alexander
Kornprat Peter
Pichler Martin
Samonigg Hellmut
Schaberl-Moser Renate
Stojakovic Tatjana
Stotz Michael
Weissmüller Melanie

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Recent evidence indicates that tumor progression involves factors of systemic inflammation, such as platelets and lymphocytes. In this study, we investigated the prognostic relevance of the preoperative platelet to lymphocyte (P/L) ratio on time to recurrence (TTR) and overall survival (OS) in patients with stage II and III colon cancer (CC) who underwent curative resection. In this retrospective study, 372 CC patients were included. Kaplan-Meier curves and multivariate Cox proportional models were calculated for TTR and OS. In univariate analysis, the elevated P/L ratio was significantly associated with decreased TTR (HR = 1.60, 95% CI = 1.02 to 2.51, P = .040) and remained significant in multivariate analysis (HR = 1.65, 95% CI = 1.05 to 2.58, P = .030), where HR and CI represent Hazard ratio and confidence interval, respectively. Patients with elevated P/L ratio showed a median TTR of 116 months. In contrast, patients with low P/L ratio had a median TTR of 132 months. In OS analysis, the elevated P/L ratio showed a trend toward decreased OS in univariate analysis (HR = 1.54, 95% CI = .95 to 2.48, P = .079). In this study, we identified the preoperative P/L ratio as a prognostic marker for TTR in stage II and III CC patients. Copyright © 2014 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Colonic Neoplasms - blood Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colonic Neoplasms - surgery
Female -
Humans -
Lymphocyte Count -
Male -
Middle Aged -
Multivariate Analysis -
Neoplasm Recurrence, Local - blood
Platelet Count -
Preoperative Period -
Prognosis -
Retrospective Studies -
Time Factors -

Find related publications in this database (Keywords)
Platelet to lymphocyte ratio
Systemic inflammation
Colon cancer
Prognostic factor
© Med Uni Graz Impressum