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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Wardlaw, JM; Smith, EE; Biessels, GJ; Cordonnier, C; Fazekas, F; Frayne, R; Lindley, RI; O'Brien, JT; Barkhof, F; Benavente, OR; Black, SE; Brayne, C; Breteler, M; Chabriat, H; DeCarli, C; de Leeuw, FE; Doubal, F; Duering, M; Fox, NC; Greenberg, S; Hachinski, V; Kilimann, I; Mok, V; van Oostenbrugge, R; Pantoni, L; Speck, O; Stephan, BCM; Teipel, S; Viswanathan, A; Werring, D; Chen, C; Smith, C; van Buchem, M; Norrving, B; Gorelick, PB; Dichgans, M.
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
LANCET NEUROL. 2013; 12(8): 822-838. Doi: 10.1016/S1474-4422(13)70124-8 [OPEN ACCESS]
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Fazekas Franz

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Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities, perivascular spaces, microbleeds, and brain atrophy. SVD can present as a stroke or cognitive decline, or can have few or no symptoms. SVD frequently coexists with neurodegenerative disease, and can exacerbate cognitive deficits, physical disabilities, and other symptoms of neurodegeneration. Terminology and definitions for imaging the features of SVD vary widely, which is also true for protocols for image acquisition and image analysis. This lack of consistency hampers progress in identifying the contribution of SVD to the pathophysiology and clinical features of common neurodegenerative diseases. We are an international working group from the Centres of Excellence in Neurodegeneration. We completed a structured process to develop definitions and imaging standards for markers and consequences of SVD. We aimed to achieve the following: first, to provide a common advisory about terms and definitions for features visible on MRI; second, to suggest minimum standards for image acquisition and analysis; third, to agree on standards for scientific reporting of changes related to SVD on neuroimaging; and fourth, to review emerging imaging methods for detection and quantification of preclinical manifestations of SVD. Our findings and recommendations apply to research studies, and can be used in the clinical setting to standardise image interpretation, acquisition, and reporting. This Position Paper summarises the main outcomes of this international effort to provide the STandards for ReportIng Vascular changes on nEuroimaging (STRIVE). Copyright © 2013 Elsevier Ltd. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Aging -
Cerebral Small Vessel Diseases - classification Cerebral Small Vessel Diseases - complications Cerebral Small Vessel Diseases - diagnosis
Female -
Guidelines as Topic -
Humans -
Image Processing, Computer-Assisted -
International Cooperation -
Male -
Neurodegenerative Diseases - diagnosis
Neuroimaging - classification Neuroimaging - methods Neuroimaging - standards
Terminology as Topic -

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