Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Absenger, G; Szkandera, J; Stotz, M; Postlmayr, U; Pichler, M; Ress, AL; Schaberl-Moser, R; Loibner, H; Samonigg, H; Gerger, A.
Preoperative neutrophil-to-lymphocyte ratio predicts clinical outcome in patients with stage II and III colon cancer.
Anticancer Res. 2013; 33(10):4591-4594
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Absenger Gudrun
- Gerger Armin
- Co-Autor*innen der Med Uni Graz
- Lembeck Anna Lena
- Pichler Martin
- Samonigg Hellmut
- Schaberl-Moser Renate
- Stotz Michael
- Szkandera Joanna
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- Abstract:
- Aim/Background: The neutrophil-to-lymphocyte ratio (NLR), a combined indicator of inflammation and immunology, is as yet unidentified regarding the clinical outcome of stage II and III colon cancer patients. We evaluated the effect of NLR on time-to-recurrence (TTR) and overall survival (OS) in selected patients. Patients and Methods: A total of 504 patients with stage II and III colon cancer were included in this retrospective study. Preoperative NLR with a cut-off level of 4 was associated with TTR and OS. Results: In univariate analysis, elevated NLR was significantly associated with decreased TTR (p=0.001) and remained significant in multivariate analysis (p=0.006). Patients with NLR >4 showed a median TTR of 62.2 months. In contrast, patients with NLR <= 4 had a median TTR of 92.6 months. Conclusion: This study suggests that preoperative NLR may be an independent prognostic marker for TTR in stage II and III colon cancer patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Colonic Neoplasms - immunology Colonic Neoplasms - mortality Colonic Neoplasms - pathology
- Disease-Free Survival -
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Lymphocyte Count -
- Lymphocytes - immunology
- Male -
- Middle Aged -
- Multivariate Analysis -
- Neoplasm Staging -
- Neutrophils - immunology
- Preoperative Period -
- Prognosis -
- Proportional Hazards Models -
- Retrospective Studies -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- Neutrophil-to-lymphocyte ratio
- colon cancer