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Dalpiaz, O; Ehrlich, GC; Mannweiler, S; Hernández, JM; Gerger, A; Stojakovic, T; Pummer, K; Zigeuner, R; Pichler, M; Hutterer, GC.
Validation of pretreatment neutrophil-lymphocyte ratio as a prognostic factor in a European cohort of patients with upper tract urothelial carcinoma.
BJU Int. 2014; 114(3):334-339 Doi: 10.1111/bju.12441 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Dalpiaz Orietta
Pichler Martin
Co-Autor*innen der Med Uni Graz
Ehrlich Georg
Gerger Armin
Hutterer Georg
Mannweiler Sebastian
Martin Hernandez Jessica Maria
Pummer Karl
Stojakovic Tatjana
Zigeuner Richard

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To investigate the potential prognostic significance of the neutrophil-lymphocyte ratio (NLR) in a large European cohort of patients with upper urinary tract urothelial cell carcinoma (UUT-UCC). We retrospectively evaluated data from 202 consecutive patients with non-metastatic upper urinary tract urothelial cell carcinoma (UUT-UCC), who underwent surgery between 1990 and 2012 at a single tertiary academic centre. Patients' cancer-specific survival (CSS) and overall survival (OS) were assessed using the Kaplan-Meier method. To evaluate the independent prognostic significance of the NLR, multivariate proportional Cox regression models were applied for both endpoints. A higher NLR was significantly associated with shorter CSS (P = 0.002, log-rank test), as well as with shorter OS (P < 0.001, log-rank test). Multivariate analysis identified a high NLR as an independent prognostic factor for patients' CSS (hazard ratio 2.72, 95% CI 1.25-5.93, P = 0.012), and OS (hazard ratio 2.48, 95% CI 1.31-4.70, P = 0.005). In the present cohort, patients with a high preoperative NLR had higher cancer-specific and overall mortality after radical surgery for UUT-UCC, compared with those with a low preoperative NLR. This easily identifiable laboratory measure should be considered as an additional prognostic factor in UUT-UCC in future. © 2013 The Authors. BJU International © 2013 BJU International.
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Biomarkers, Tumor - immunology
Carcinoma, Transitional Cell - immunology
Carcinoma, Transitional Cell - mortality
Carcinoma, Transitional Cell - pathology
Disease Progression -
Disease-Free Survival -
Disease-Free Survival -
Female -
Humans -
Inflammation - immunology
Inflammation - pathology
Lymphocytes - immunology
Male -
Neutrophils - immunology
Preoperative Care -
Prognosis -
Proportional Hazards Models -
Retrospective Studies -
Ureteral Neoplasms - immunology
Ureteral Neoplasms - mortality
Ureteral Neoplasms - pathology
Urothelium - pathology

Find related publications in this database (Keywords)
neutrophil-lymphocyte ratio
upper tract urothelial carcinoma
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