Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dalpiaz, O; Ehrlich, GC; Mannweiler, S; Hernández, JM; Gerger, A; Stojakovic, T; Pummer, K; Zigeuner, R; Pichler, M; Hutterer, GC.
Validation of pretreatment neutrophil-lymphocyte ratio as a prognostic factor in a European cohort of patients with upper tract urothelial carcinoma.
BJU Int. 2014; 114(3):334-339
Doi: 10.1111/bju.12441
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- Führende Autor*innen der Med Uni Graz
- Dalpiaz Orietta
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Ehrlich Georg
- Gerger Armin
- Hutterer Georg
- Mannweiler Sebastian
- Martin Hernandez Jessica Maria
- Pummer Karl
- Stojakovic Tatjana
- Zigeuner Richard
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- Abstract:
- To investigate the potential prognostic significance of the neutrophil-lymphocyte ratio (NLR) in a large European cohort of patients with upper urinary tract urothelial cell carcinoma (UUT-UCC). We retrospectively evaluated data from 202 consecutive patients with non-metastatic upper urinary tract urothelial cell carcinoma (UUT-UCC), who underwent surgery between 1990 and 2012 at a single tertiary academic centre. Patients' cancer-specific survival (CSS) and overall survival (OS) were assessed using the Kaplan-Meier method. To evaluate the independent prognostic significance of the NLR, multivariate proportional Cox regression models were applied for both endpoints. A higher NLR was significantly associated with shorter CSS (P = 0.002, log-rank test), as well as with shorter OS (P < 0.001, log-rank test). Multivariate analysis identified a high NLR as an independent prognostic factor for patients' CSS (hazard ratio 2.72, 95% CI 1.25-5.93, P = 0.012), and OS (hazard ratio 2.48, 95% CI 1.31-4.70, P = 0.005). In the present cohort, patients with a high preoperative NLR had higher cancer-specific and overall mortality after radical surgery for UUT-UCC, compared with those with a low preoperative NLR. This easily identifiable laboratory measure should be considered as an additional prognostic factor in UUT-UCC in future. © 2013 The Authors. BJU International © 2013 BJU International.
- Find related publications in this database (using NLM MeSH Indexing)
- Biomarkers, Tumor - immunology
- Carcinoma, Transitional Cell - immunology
- Carcinoma, Transitional Cell - mortality
- Carcinoma, Transitional Cell - pathology
- Disease Progression -
- Disease-Free Survival -
- Disease-Free Survival -
- Female -
- Humans -
- Inflammation - immunology
- Inflammation - pathology
- Lymphocytes - immunology
- Male -
- Neutrophils - immunology
- Preoperative Care -
- Prognosis -
- Proportional Hazards Models -
- Retrospective Studies -
- Ureteral Neoplasms - immunology
- Ureteral Neoplasms - mortality
- Ureteral Neoplasms - pathology
- Urothelium - pathology
- Find related publications in this database (Keywords)
- neutrophil-lymphocyte ratio
- prognosis
- upper tract urothelial carcinoma