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Luers, C; Sutcliffe, A; Binder, L; Irle, S; Pieske, B.
NT-proANP and NT-proBNP as prognostic markers in patients with acute decompensated heart failure of different etiologies.
CLIN BIOCHEM. 2013; 46(12): 1013-1019. Doi: 10.1016/j.clinbiochem.2013.03.014
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Co-Autor*innen der Med Uni Graz
Binder Lukas
Pieske Burkert Mathias

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Peak NT-proANP and NT-proBNP plasma levels after hospital admission may be of additional prognostic value in patients with acute decompensation of heart failure. The time-course of natriuretic plasma levels after hospital admission, and a possible influence of the underlying etiology on the time-course have not been sufficiently investigated. Natriuretic peptide plasma levels of 85 patients with decompensated heart failure from ischemic and non-ischemic origins were measured at baseline and at 12h after hospital admission. NT-proBNP plasma levels on admission were lower compared to 12-hour-plasma levels, whereas NT-proANP plasma levels on admission were higher compared to 12-hour-plasma levels. Twenty-six patients (31%) died within the first 30 days. In patients who died within the first 30 days after admission NT-proANP and NT-proBNP plasma levels on admission and 12h later were significantly higher compared to survivors. Irrespective of different etiologies NT-proANP on admission and NT-proBNP 12h after admission were highest and demonstrated superior impact with respect to the prediction of 30-day-mortality. NT-proANP and NT-proBNP are powerful markers of 30-day-mortality in patients with acute heart failure of ischemic and non-ischemic origins. With respect to the prediction of 30-day-mortality, NT-proBNP plasma levels at 12h after admission are comparable with NT-proANP plasma levels on admission. These data underline the fact that with regard to etiology-dependent hemodynamic changes and plasma half-time, the determination of peak plasma levels is of highest importance for the estimation of the impact of natriuretic peptides on the prognosis of patients with decompensated heart failure. Copyright © 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing)
Acute Disease -
Aged -
Atrial Natriuretic Factor - blood
Biological Markers - blood
Female -
Heart Failure - blood
Hospitalization -
Humans -
Kaplan-Meier Estimate -
Male -
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
Prognosis -
ROC Curve -
Regression Analysis -
Stroke Volume -
Survival Analysis -

Find related publications in this database (Keywords)
Heart failure
Decompensated heart failure
Natriuretic peptides
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