Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pichler, M; Hutterer, GC; Stojakovic, T; Mannweiler, S; Pummer, K; Zigeuner, R.
High plasma fibrinogen level represents an independent negative prognostic factor regarding cancer-specific, metastasis-free, as well as overall survival in a European cohort of non-metastatic renal cell carcinoma patients.
Br J Cancer. 2013; 109(5):1123-1129
Doi: 10.1038/bjc.2013.443
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- Führende Autor*innen der Med Uni Graz
- Pichler Martin
- Stojakovic Tatjana
- Co-Autor*innen der Med Uni Graz
- Hutterer Georg
- Mannweiler Sebastian
- Pummer Karl
- Zigeuner Richard
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- Abstract:
- Background: In recent years, plasma fibrinogen has been ascribed an important role in the pathophysiology of tumour cell invasion and metastases. A relatively small-scale study has indicated that plasma fibrinogen levels may serve as a prognostic factor for predicting clinical outcomes in non-metastatic renal cell carcinoma (RCC) patients. Methods: Data from 994 consecutive non-metastatic RCC patients, operated between 2000 and 2010 at a single, tertiary academic centre, were evaluated. Analyses of plasma fibrinogen levels were performed one day before the surgical interventions. Patients were categorised using a cut-off value of 466 mg dl(-1) according to a calculation by receiver-operating curve analysis. Cancer-specific (CSS), metastasis-free (MFS), as well as overall survival (OS) were assessed using the Kaplan-Meier method. To evaluate the independent prognostic impact of plasma fibrinogen level, a multivariable Cox regression model was performed for all three different endpoints. Results: High plasma fibrinogen levels were associated with various well-established prognostic factors, including age, advanced tumour stage, tumour grade and histologic tumour necrosis (all P < 0.05). Furthermore, in multivariable analysis, a high plasma fibrinogen level was statistically significantly associated with a poor outcome for patients' CSS (hazard ratio (HR): 2.47, 95% confidence interval (CI): 1.49-4.11, P < 0.001), MFS (HR: 2.15, 95% CI: 1.44-3.22, P < 0.001) and OS (HR: 2.48, 95% CI: 1.80-3.40, P < 0.001). Conclusion: A high plasma fibrinogen level seems to represent a strong and independent negative prognostic factor regarding CSS, MFS and OS in non-metastatic RCC patients. Thus, this easily determinable laboratory value should be considered as an additional prognostic factor for RCC patients' individual risk assessment.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Renal Cell - blood
- Cohort Studies -
- Cohort Studies -
- Female -
- Fibrinogen - analysis
- Humans -
- Kidney Neoplasms - blood
- Male -
- Middle Aged -
- Neoplasm Metastasis -
- Risk Assessment -
- Survival Rate -
- Treatment Outcome -
- Tumor Markers, Biological - blood
- Find related publications in this database (Keywords)
- fibrinogen
- prognosis
- renal cell carcinoma
- validation