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Pichler, M; Hutterer, GC; Stojakovic, T; Mannweiler, S; Pummer, K; Zigeuner, R.
High plasma fibrinogen level represents an independent negative prognostic factor regarding cancer-specific, metastasis-free, as well as overall survival in a European cohort of non-metastatic renal cell carcinoma patients.
Br J Cancer. 2013; 109(5):1123-1129 Doi: 10.1038/bjc.2013.443 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Pichler Martin
Stojakovic Tatjana
Co-Autor*innen der Med Uni Graz
Hutterer Georg
Mannweiler Sebastian
Pummer Karl
Zigeuner Richard

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Background: In recent years, plasma fibrinogen has been ascribed an important role in the pathophysiology of tumour cell invasion and metastases. A relatively small-scale study has indicated that plasma fibrinogen levels may serve as a prognostic factor for predicting clinical outcomes in non-metastatic renal cell carcinoma (RCC) patients. Methods: Data from 994 consecutive non-metastatic RCC patients, operated between 2000 and 2010 at a single, tertiary academic centre, were evaluated. Analyses of plasma fibrinogen levels were performed one day before the surgical interventions. Patients were categorised using a cut-off value of 466 mg dl(-1) according to a calculation by receiver-operating curve analysis. Cancer-specific (CSS), metastasis-free (MFS), as well as overall survival (OS) were assessed using the Kaplan-Meier method. To evaluate the independent prognostic impact of plasma fibrinogen level, a multivariable Cox regression model was performed for all three different endpoints. Results: High plasma fibrinogen levels were associated with various well-established prognostic factors, including age, advanced tumour stage, tumour grade and histologic tumour necrosis (all P < 0.05). Furthermore, in multivariable analysis, a high plasma fibrinogen level was statistically significantly associated with a poor outcome for patients' CSS (hazard ratio (HR): 2.47, 95% confidence interval (CI): 1.49-4.11, P < 0.001), MFS (HR: 2.15, 95% CI: 1.44-3.22, P < 0.001) and OS (HR: 2.48, 95% CI: 1.80-3.40, P < 0.001). Conclusion: A high plasma fibrinogen level seems to represent a strong and independent negative prognostic factor regarding CSS, MFS and OS in non-metastatic RCC patients. Thus, this easily determinable laboratory value should be considered as an additional prognostic factor for RCC patients' individual risk assessment.
Find related publications in this database (using NLM MeSH Indexing)
Carcinoma, Renal Cell - blood
Cohort Studies -
Cohort Studies -
Female -
Fibrinogen - analysis
Humans -
Kidney Neoplasms - blood
Male -
Middle Aged -
Neoplasm Metastasis -
Risk Assessment -
Survival Rate -
Treatment Outcome -
Tumor Markers, Biological - blood

Find related publications in this database (Keywords)
renal cell carcinoma
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