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Kienreich, K; Tomaschitz, A; Verheyen, N; Pieber, T; Gaksch, M; Grübler, MR; Pilz, S.
Vitamin D and cardiovascular disease.
Nutrients. 2013; 5(8):3005-21 Doi: 10.3390/nu5083005 [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz
Kienreich Katharina
Co-Autor*innen der Med Uni Graz
Grübler Martin
Keppel Martin
Pieber Thomas
Pilz Stefan
Tomaschitz Andreas
Verheyen Nicolas Dominik

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Vitamin D deficiency, as well as cardiovascular diseases (CVD) and related risk factors are highly prevalent worldwide and frequently co-occur. Vitamin D has long been known to be an essential part of bone metabolism, although recent evidence suggests that vitamin D plays a key role in the pathophysiology of other diseases, including CVD, as well. In this review, we aim to summarize the most recent data on the involvement of vitamin D deficiency in the development of major cardiovascular risk factors: hypertension, obesity and dyslipidemia, type 2 diabetes, chronic kidney disease and endothelial dysfunction. In addition, we outline the most recent observational, as well as interventional data on the influence of vitamin D on CVD. Since it is still an unresolved issue whether vitamin D deficiency is causally involved in the pathogenesis of CVD, data from randomized controlled trials (RCTs) designed to assess the impact of vitamin D supplementation on cardiovascular outcomes are awaited with anticipation. At present, we can only conclude that vitamin D deficiency is an independent cardiovascular risk factor, but whether vitamin D supplementation can significantly improve cardiovascular outcomes is still largely unknown.
Find related publications in this database (using NLM MeSH Indexing)
Cardiovascular Diseases - complications, prevention & control
Dietary Supplements - administration & dosage
Humans - administration & dosage
Observational Studies as Topic - administration & dosage
Prevalence - administration & dosage
Randomized Controlled Trials as Topic - administration & dosage
Risk Factors - administration & dosage
Treatment Outcome - administration & dosage
Vitamin D - administration & dosage, blood
Vitamin D Deficiency - complications, drug therapy, epidemiology

Find related publications in this database (Keywords)
vitamin D
vitamin D deficiency
cardiovascular disease
cardiovascular risk factors
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