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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Pinter, D; Pegritz, S; Pargfrieder, C; Reiter, G; Wurm, W; Gattringer, T; Linderl-Madrutter, R; Neuper, C; Fazekas, F; Grieshofer, P; Enzinger, C.
Exploratory study on the effects of a robotic hand rehabilitation device on changes in grip strength and brain activity after stroke.
Top Stroke Rehabil. 2013; 20(4):308-316 Doi: 10.1310/tsr2004-308
Web of Science PubMed FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Pinter Daniela Theresia
Co-Autor*innen der Med Uni Graz
Enzinger Christian
Fazekas Franz
Gattringer Thomas
Reiter Gudrun
Wurm Walter Ernst

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The brain mechanisms underlying successful recovery of hand fuenction after stroke are still not fully understood, although functional MRI (fMRI) studies underline the importance of neuronal plasticity. We explored potential changes in brain activity in 7 patients with subacute to chronic stroke (69 ± 8 years) with moderate- to high-grade distal paresis of the upper limb (Motricity Index: 59.4) after standardized robotic finger-hand rehabilitation training, in addition to conventional rehabilitation therapy for 3 weeks. Behavioral and fMRI assessments were carried out before and after training to characterize changes in brain activity and behavior. The Motricity Index (pre: 59.4, post: 67.2, P < .05) and grip force (pre: 7.26, post: 11.87, P < .05) of the paretic hand increased significantly after rehabilitation. On fMRI, active movement of the affected (left) hand resulted in contralesional (ie, ipsilateral) activation of the primary sensorimotor cortex prior to rehabilitation. After rehabilitation, activation appeared "normalized," including the ipsilesional primary sensorimotor cortex and supplementary motor area (SMA). No changes and no abnormalities of activation maps were seen during movement of the unaffected hand. Subsequent region-of-interest analyses showed no significant ipsilesional activation increases after rehabilitation. Despite behavioral improvements, we failed to identify consistent patterns of functional reorganization in our sample. This warrants caution in the use of fMRI as a tool to explore neural plasticity in heterogeneous samples lacking sufficient statistical power.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Brain - pathology
Female -
Functional Laterality - physiology
Hand - physiopathology
Hand Strength - physiology
Humans -
Image Processing, Computer-Assisted -
Magnetic Resonance Imaging -
Male -
Middle Aged -
Outcome Assessment (Health Care) -
Oxygen - blood
Psychomotor Performance -
Robotics - instrumentation Robotics - methods
Somatosensory Cortex - blood supply Somatosensory Cortex - physiopathology
Stroke - pathology Stroke - physiopathology Stroke - rehabilitation

Find related publications in this database (Keywords)
functional MRI
motor recovery
robotic devices
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