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Eisner, F; Schaberl-Moser, R; Gerger, A; Samonigg, H; Pichler, M.
Successful use of sorafenib after bortezomib failure in metastatic follicular thyroid cancer - a case report.
Onkologie. 2013; 36(6):368-370 Doi: 10.1159/000351252 (- Case Report)
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Führende Autor*innen der Med Uni Graz
Eisner Florian
Pichler Martin
Co-Autor*innen der Med Uni Graz
Gerger Armin
Samonigg Hellmut
Schaberl-Moser Renate

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Background: Thyroid cancer (TC) is the most commonly diagnosed endocrine malignancy in developed countries. Differentiated thyroid carcinoma (DTC), which includes papillary thyroid carcinoma and follicular thyroid carcinoma (FTC), composes more than 90% of all TC cases. When DTC recurs or metastasizes to distant sites despite the use of local and radiotherapeutic treatment modalities, the currently effective treatment options are limited. Case Report: A then 40-year-old female Caucasian patient was diagnosed with FTC and underwent surgery and postoperative radioactive iodine therapy. The patient developed metastatic disease, and palliative first-line treatment with the proteasome inhibitor bortezomib was initiated. After 3 months, the patient suffered progressive pulmonary metastatic disease. Treatment with the multikinase inhibitor sorafenib was started, and after 3 months of therapy, tumor restaging demonstrated partial remission. The treatment is ongoing, and the current progression-free survival is 16 months. With the exception of mild diarrhea and hand-foot syndrome, the therapy was well tolerated, and no grade 3/4 adverse toxicities occurred. Conclusion: In our single case of metastatic FTC, sorafenib showed clinically meaningful antitumor activity accompanied by good tolerability. This case report supports the use of this drug as a potential treatment option for advanced/metastatic FTC.
Find related publications in this database (using NLM MeSH Indexing)
Adenocarcinoma, Follicular - diagnosis Adenocarcinoma, Follicular - drug therapy
Adult -
Boronic Acids - therapeutic use
Female -
Humans -
Kidney Neoplasms - diagnosis Kidney Neoplasms - drug therapy Kidney Neoplasms - secondary
Lung Neoplasms - diagnosis Lung Neoplasms - drug therapy Lung Neoplasms - secondary
Niacinamide - analogs & derivatives Niacinamide - therapeutic use
Phenylurea Compounds - therapeutic use
Pyrazines - therapeutic use
Thyroid Neoplasms - diagnosis Thyroid Neoplasms - drug therapy
Treatment Failure -
Treatment Outcome -

Find related publications in this database (Keywords)
Follicular thyroid cancer
Palliative treatment
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