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Birkl, C; Langkammer, C; Haybaeck, J; Ernst, C; Stollberger, R; Fazekas, F; Ropele, S.
Temperature-induced changes of magnetic resonance relaxation times in the human brain: a postmortem study.
Magn Reson Med. 2014; 71(4):1575-1580 Doi: 10.1002/mrm.24799
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Führende Autor*innen der Med Uni Graz
Birkl Christoph
Ropele Stefan
Co-Autor*innen der Med Uni Graz
Ernst Christina
Fazekas Franz
Haybäck Johannes
Langkammer Christian
Stollberger Rudolf

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Magnetic resonance relaxation times of most tissues are expected to depend on temperature, which can impact findings in postmortem magnetic resonance imaging or when using magnetic resonance imaging for relaxation-based thermometry. The purpose of this study was to investigate the exact temperature dependency of the relaxation times T(1), T(2), T(2) *, and the magnetization transfer ratio in different structures of the human brain. To prevent fixation and autolysis effects, this study was performed with fresh postmortem brain tissues. Following autopsy, coronal brain slices from five deceased subjects were subjected to relaxometry at 3T in a temperature range between 4°C and 37°C. Heating of the tissue was achieved by flushing the vacuum packed brain slices with water at a predefined temperature. T1 showed a linear dependency on temperature with the highest temperature coefficient in the cortex (17.4 ms/°C) and the lowest in the white matter (3.4 ms/°C). T(2) did not depend on temperature. T(2) * and magnetization transfer ratio scaled with temperature only in deep gray matter. The temperature coefficient for T(1) is higher than expected from previous reports and varies across brain structures. The coefficients obtained in this study can serve as reference for thermometry or for correcting quantitative postmortem magnetic resonance imaging. Copyright © 2013 Wiley Periodicals, Inc.
Find related publications in this database (using NLM MeSH Indexing)
Aged -
Aged, 80 and over -
Body Temperature -
Brain - pathology Brain - physiology
Cadaver -
Female -
Humans -
Image Interpretation, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Male -
Middle Aged -
Postmortem Changes -
Reproducibility of Results -
Sensitivity and Specificity -

Find related publications in this database (Keywords)
temperature dependency
magnetic resonance imaging
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