Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Woitas, RP; Kleber, ME; Meinitzer, A; Grammer, TB; Silbernagel, G; Pilz, S; Tomaschitz, A; Weihrauch, G; Dobnig, H; März, W; Scharnagl, H.
Cystatin C is independently associated with total and cardiovascular mortality in individuals undergoing coronary angiography. The Ludwigshafen Risk and Cardiovascular Health (LURIC) study.
Atherosclerosis. 2013; 229(2):541-548
Doi: 10.1016/j.atherosclerosis.2013.04.027
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- Co-Autor*innen der Med Uni Graz
- Dobnig Harald
- März Winfried
- Meinitzer Andreas
- Pilz Stefan
- Scharnagl Hubert
- Silbernagel Günther
- Tomaschitz Andreas
- Weihrauch Gisela
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- Abstract:
- Cystatin C is a well established marker of kidney function. There is evidence that cystatin C concentrations are also associated with mortality. The present analysis prospectively evaluated the associations of cystatin C with all-cause and cardiovascular (CV) mortality in a well-characterized cohort of persons undergoing angiography, but without overt renal insufficiency. Cystatin C was available in 2998 persons (mean age: 62.7 ± 10.5 years; 30.3% women). Of those 2346 suffered from coronary artery disease (CAD) and 652 (controls) did not. Creatinine (mean ± SD: 83.1 ± 47.8 vs. 74.1 ± 24.7 μmol/L, p = 0.036) but not Cystatin C (mean ± SD: 1.02 ± 0.44 vs. 0.92 ± 0.26 mg/L, p = 0.065) was significantly higher in patients with CAD. After a median follow-up of 9.9 years, in total 898 (30%) deaths occurred, 554 (18.5%) due to CV disease and 326 (10.9%) due to non-CV causes. Multivariable-adjusted Cox analysis (adjusting for eGFR and established cardiovascular risk factors, lipid lowering therapy, angiographic coronary artery disease, and C-reactive protein) revealed that patients in the highest cystatin C quartile were at an increased risk for all-cause (hazard ratio (HR) 1.93, 95% CI 1.50-2.48) and CV mortality (HR 2.05 95% CI 1.48-2.84) compared to those in the lowest quartile. The addition of cystatin C to a model consisting of established cardiovascular risk factors increased the area under the receiver-operating characteristic curve for CV and all-cause mortality, but the difference was statistically not significant. However, reclassification analysis revealed significant improvement by addition of cystatin C for CV and all-cause mortality (p < 0.001), respectively. The concentration of cystatin C is strongly associated with long-term all-cause and cardiovascular mortality in patients referred to coronary angiography, irrespective of creatinine-based renal function. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- C-Reactive Protein - metabolism
- Cholesterol, HDL - blood
- Cholesterol, LDL - blood
- Coronary Angiography - mortality
- Coronary Artery Disease - blood Coronary Artery Disease - mortality Coronary Artery Disease - radiography
- Creatinine - blood
- Cystatin C - blood
- Female -
- Glomerular Filtration Rate -
- Humans -
- Kidney Function Tests -
- Male -
- Middle Aged -
- Models, Biological -
- Proportional Hazards Models -
- Prospective Studies -
- Risk Factors -
- Find related publications in this database (Keywords)
- Cystatin C
- Renal function
- eGFR
- Mortality
- Coronary artery disease