Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
von Sarnowski, B; Schminke, U; Tatlisumak, T; Putaala, J; Grittner, U; Kaps, M; Tobin, WO; Kinsella, JA; McCabe, DJ; Hennerici, MG; Fazekas, F; Norrving, B; Kessler, C; Rolfs, A; sifap1 investigators.
Prevalence of stenoses and occlusions of brain-supplying arteries in young stroke patients.
Neurology. 2013; 80(14):1287-1294
Doi: 10.1212/WNL.0b013e31828ab2ed
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
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- Abstract:
- Atherosclerosis is believed to be a minor cause of TIA and stroke in younger and middle-aged patients. However, data from large cohorts are limited. This study investigates the prevalence of extracranial and intracranial atherosclerosis in stroke and TIA patients aged 18-55 years in the multinational sifap1 study. From the sifap1 cohort (n = 5,023), we analyzed a subset of patients with complete data from carotid ultrasound studies. Patients with arterial dissections, vasculitis, and mobile thrombi were excluded. Among the remaining 2,187 patients (men: n = 1,319; 18-44 years: n = 744), intracranial arteries were additionally examined with ultrasonography in 1,612 patients (73.7%). Patients were stratified by sex and age groups (younger: 18-44 years; middle-aged: 45-55 years). In patients with ischemic stroke, the overall prevalence of carotid artery stenoses and occlusions was 8.9% (younger: 4.9%; middle-aged: 11.0%), of which 81% were symptomatic. Nonstenotic carotid plaques were more common in men than in women (15.8% vs. 7.7%; p < 0.001), and in middle-aged than in younger patients (17.0% vs. 4.9%; p < 0.001). Supratentorial intracranial artery stenoses and occlusions amounted to 11.8%. Supratentorial stenoses occurred more frequently in middle-aged patients (13.0% vs. 7.8%; p < 0.001), whereas occlusions were equally common (both 3.2%; not significant). We observed a substantial proportion of atherosclerotic carotid artery stenoses and occlusions in younger stroke patients. Intracranial stenoses and occlusions were even more prevalent than extracranial carotid artery disease. Together with nonstenotic plaques, one-fifth of patients (21.2%) had symptomatic or asymptomatic large-artery atherosclerosis, which should encourage future stroke prevention campaigns to target risk factor modification in young people.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Carotid Stenosis - epidemiology Carotid Stenosis - ultrasonography
- Cerebral Arteries - pathology Cerebral Arteries - ultrasonography
- Cohort Studies -
- Constriction, Pathologic - epidemiology Constriction, Pathologic - pathology
- Electrocardiography -
- Female -
- Humans -
- Intracranial Arteriosclerosis - epidemiology Intracranial Arteriosclerosis - ultrasonography
- Ischemic Attack, Transient - epidemiology Ischemic Attack, Transient - ultrasonography
- Logistic Models -
- Male -
- Prevalence -
- Retrospective Studies -
- Ultrasonography, Doppler, Transcranial -
- Young Adult -