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SHR Neuro Krebs Kardio Lipid Stoffw Microb

von Sarnowski, B; Schminke, U; Tatlisumak, T; Putaala, J; Grittner, U; Kaps, M; Tobin, WO; Kinsella, JA; McCabe, DJ; Hennerici, MG; Fazekas, F; Norrving, B; Kessler, C; Rolfs, A; sifap1 investigators.
Prevalence of stenoses and occlusions of brain-supplying arteries in young stroke patients.
Neurology. 2013; 80(14):1287-1294 Doi: 10.1212/WNL.0b013e31828ab2ed
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Co-Autor*innen der Med Uni Graz
Fazekas Franz

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Atherosclerosis is believed to be a minor cause of TIA and stroke in younger and middle-aged patients. However, data from large cohorts are limited. This study investigates the prevalence of extracranial and intracranial atherosclerosis in stroke and TIA patients aged 18-55 years in the multinational sifap1 study. From the sifap1 cohort (n = 5,023), we analyzed a subset of patients with complete data from carotid ultrasound studies. Patients with arterial dissections, vasculitis, and mobile thrombi were excluded. Among the remaining 2,187 patients (men: n = 1,319; 18-44 years: n = 744), intracranial arteries were additionally examined with ultrasonography in 1,612 patients (73.7%). Patients were stratified by sex and age groups (younger: 18-44 years; middle-aged: 45-55 years). In patients with ischemic stroke, the overall prevalence of carotid artery stenoses and occlusions was 8.9% (younger: 4.9%; middle-aged: 11.0%), of which 81% were symptomatic. Nonstenotic carotid plaques were more common in men than in women (15.8% vs. 7.7%; p < 0.001), and in middle-aged than in younger patients (17.0% vs. 4.9%; p < 0.001). Supratentorial intracranial artery stenoses and occlusions amounted to 11.8%. Supratentorial stenoses occurred more frequently in middle-aged patients (13.0% vs. 7.8%; p < 0.001), whereas occlusions were equally common (both 3.2%; not significant). We observed a substantial proportion of atherosclerotic carotid artery stenoses and occlusions in younger stroke patients. Intracranial stenoses and occlusions were even more prevalent than extracranial carotid artery disease. Together with nonstenotic plaques, one-fifth of patients (21.2%) had symptomatic or asymptomatic large-artery atherosclerosis, which should encourage future stroke prevention campaigns to target risk factor modification in young people.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Carotid Stenosis - epidemiology Carotid Stenosis - ultrasonography
Cerebral Arteries - pathology Cerebral Arteries - ultrasonography
Cohort Studies -
Constriction, Pathologic - epidemiology Constriction, Pathologic - pathology
Electrocardiography -
Female -
Humans -
Intracranial Arteriosclerosis - epidemiology Intracranial Arteriosclerosis - ultrasonography
Ischemic Attack, Transient - epidemiology Ischemic Attack, Transient - ultrasonography
Logistic Models -
Male -
Prevalence -
Retrospective Studies -
Ultrasonography, Doppler, Transcranial -
Young Adult -

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