Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Absenger, G; Benhaim, L; Szkandera, J; Zhang, W; Yang, D; Labonte, MJ; Pichler, M; Stotz, M; Samonigg, H; Renner, W; Gerger, A; Lenz, HJ.
The cyclin D1 (CCND1) rs9344 G>A polymorphism predicts clinical outcome in colon cancer patients treated with adjuvant 5-FU-based chemotherapy.
Pharmacogenomics J. 2014; 14(2):130-134
Doi: 10.1038/tpj.2013.15
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Absenger Gudrun
- Gerger Armin
- Co-Autor*innen der Med Uni Graz
- Pichler Martin
- Renner Wilfried
- Samonigg Hellmut
- Stotz Michael
- Szkandera Joanna
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- Abstract:
- Recent evidence indicates a potential prognostic and predictive value for germline polymorphisms in genes involved in cell cycle control. We investigated the effect of cyclin D1 (CCND1) rs9344 G>A in stage II/III colon cancer patients and validated the findings in an independent study cohort. For evaluation and validation set, a total of 264 and 234 patients were included. Patients treated with 5-fluorouracil-based chemotherapy, carrying the CCND1 rs9344 A/A genotype had significantly decreased time-to-tumor recurrence (TTR) in univariate analysis and multivariate analysis (hazard ratio (HR) 2.47; 95% confidence interval (CI) 1.16-5.29; P=0.019). There was no significant association between CCND1 rs9344 G>A and TTR in patients with curative surgery alone. In the validation set, the A allele of CCND1 rs9344 G>A remained significantly associated with decreased TTR in univariate and multivariate analyses (HR 1.94; 95% CI 1.05-3.58; P=0.035). CCND1 rs9344 G>A may be a predictive and/or prognostic biomarker in stage II/III colon cancer patients, however, prospective trials are warranted to confirm our findings.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Alleles -
- Chemotherapy, Adjuvant - adverse effects
- Colonic Neoplasms - drug therapy
- Colonic Neoplasms - genetics
- Colonic Neoplasms - pathology
- Cyclin D1 - genetics
- Female -
- Fluorouracil - administration & dosage
- Fluorouracil - adverse effects
- Humans -
- Male -
- Middle Aged -
- Neoplasm Recurrence, Local - drug therapy
- Neoplasm Recurrence, Local - genetics
- Polymorphism, Single Nucleotide -
- Prognosis -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- biomarker
- CCND1
- chemotherapy
- colon cancer
- polymorphism