Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Szkandera, J; Absenger, G; Liegl-Atzwanger, B; Pichler, M; Stotz, M; Samonigg, H; Glehr, M; Zacherl, M; Stojakovic, T; Gerger, A; Leithner, A.
Elevated preoperative neutrophil/lymphocyte ratio is associated with poor prognosis in soft-tissue sarcoma patients.
Br J Cancer. 2013; 108(8):1677-1683
Doi: 10.1038/bjc.2013.135
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- Führende Autor*innen der Med Uni Graz
- Gerger Armin
- Szkandera Joanna
- Co-Autor*innen der Med Uni Graz
- Absenger Gudrun
- Glehr Mathias
- Leithner Andreas
- Liegl-Atzwanger Bernadette
- Pichler Martin
- Samonigg Hellmut
- Stojakovic Tatjana
- Stotz Michael
- Zacherl Maximilian
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- Abstract:
- Background: Recent data indicate that tumour microenvironment, which is influenced by inflammatory cells, has a crucial role in cancer progression and clinical outcome of patients. In the present study, we investigated the prognostic relevance of preoperative neutrophil/lymphocyte (N/L) ratio on time to tumour recurrence (TTR) and overall survival (OS) in soft-tissue sarcoma (STS) patients who underwent curative surgical resection. Methods: In all, 260 STS patients were included in this retrospective study. Kaplan-Meier curves and multivariate Cox proportional models were calculated for TTR and OS. Results: In univariate analysis, elevated N/L ratio was significantly associated with decreased TTR (hazard ratio (HR), 2.32; 95% confidence interval (CI), 1.30-4.14; P=0.005) and remained significant in the multivariate analysis (HR, 1.98; 95% CI, 1.05-3.71; P=0.035). Patients with elevated N/L ratio showed a median TTR of 77.9 months. In contrast, patients with low N/L ratio had a median TTR of 99.1 months. Regarding OS, elevated N/L ratio was also significantly associated with decreased survival in univariate analysis (HR, 2.90; 95% CI, 1.82-4.61; P=0.001) and remained significant in multivariate analysis (HR, 1.88; 95% CI, 1.14-3.12; P=0.014). Conclusion: In conclusion, our findings suggest that an elevated preoperative N/L ratio predicts poor clinical outcome in STS patients and may serve as a cost-effective and broadly available independent prognostic biomarker.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Humans -
- Lymphocytes - pathology
- Middle Aged -
- Neutrophils - pathology
- Preoperative Care -
- Prognosis -
- Sarcoma - blood
- Treatment Outcome -
- Tumor Microenvironment -
- Young Adult -
- Find related publications in this database (Keywords)
- neutrophil/lymphocyte ratio
- soft-tissue sarcoma
- prognostic biomarker
- tumour microenvironment