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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Szkandera, J; Absenger, G; Liegl-Atzwanger, B; Pichler, M; Stotz, M; Samonigg, H; Glehr, M; Zacherl, M; Stojakovic, T; Gerger, A; Leithner, A.
Elevated preoperative neutrophil/lymphocyte ratio is associated with poor prognosis in soft-tissue sarcoma patients.
Br J Cancer. 2013; 108(8):1677-1683 Doi: 10.1038/bjc.2013.135 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG


Führende Autor*innen der Med Uni Graz
Gerger Armin
Szkandera Joanna
Co-Autor*innen der Med Uni Graz
Absenger Gudrun
Glehr Mathias
Leithner Andreas
Liegl-Atzwanger Bernadette
Pichler Martin
Samonigg Hellmut
Stojakovic Tatjana
Stotz Michael
Zacherl Maximilian

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Background: Recent data indicate that tumour microenvironment, which is influenced by inflammatory cells, has a crucial role in cancer progression and clinical outcome of patients. In the present study, we investigated the prognostic relevance of preoperative neutrophil/lymphocyte (N/L) ratio on time to tumour recurrence (TTR) and overall survival (OS) in soft-tissue sarcoma (STS) patients who underwent curative surgical resection. Methods: In all, 260 STS patients were included in this retrospective study. Kaplan-Meier curves and multivariate Cox proportional models were calculated for TTR and OS. Results: In univariate analysis, elevated N/L ratio was significantly associated with decreased TTR (hazard ratio (HR), 2.32; 95% confidence interval (CI), 1.30-4.14; P=0.005) and remained significant in the multivariate analysis (HR, 1.98; 95% CI, 1.05-3.71; P=0.035). Patients with elevated N/L ratio showed a median TTR of 77.9 months. In contrast, patients with low N/L ratio had a median TTR of 99.1 months. Regarding OS, elevated N/L ratio was also significantly associated with decreased survival in univariate analysis (HR, 2.90; 95% CI, 1.82-4.61; P=0.001) and remained significant in multivariate analysis (HR, 1.88; 95% CI, 1.14-3.12; P=0.014). Conclusion: In conclusion, our findings suggest that an elevated preoperative N/L ratio predicts poor clinical outcome in STS patients and may serve as a cost-effective and broadly available independent prognostic biomarker.
Find related publications in this database (using NLM MeSH Indexing)
Adolescent -
Adult -
Aged -
Aged, 80 and over -
Humans -
Lymphocytes - pathology
Middle Aged -
Neutrophils - pathology
Preoperative Care -
Prognosis -
Sarcoma - blood
Treatment Outcome -
Tumor Microenvironment -
Young Adult -

Find related publications in this database (Keywords)
neutrophil/lymphocyte ratio
soft-tissue sarcoma
prognostic biomarker
tumour microenvironment
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