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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Popescu, V; Agosta, F; Hulst, HE; Sluimer, IC; Knol, DL; Sormani, MP; Enzinger, C; Ropele, S; Alonso, J; Sastre-Garriga, J; Rovira, A; Montalban, X; Bodini, B; Ciccarelli, O; Khaleeli, Z; Chard, DT; Matthews, L; Palace, J; Giorgio, A; De Stefano, N; Eisele, P; Gass, A; Polman, CH; Uitdehaag, BM; Messina, MJ; Comi, G; Filippi, M; Barkhof, F; Vrenken, H; MAGNIMS Study Group.
Brain atrophy and lesion load predict long term disability in multiple sclerosis.
J Neurol Neurosurg Psychiatry. 2013; 84(10):1082-1091 Doi: 10.1136/jnnp-2012-304094
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Co-Autor*innen der Med Uni Graz
Enzinger Christian
Ropele Stefan

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Objective To determine whether brain atrophy and lesion volumes predict subsequent 10 year clinical evolution in multiple sclerosis (MS). Design From eight MAGNIMS (MAGNetic resonance Imaging in MS) centres, we retrospectively included 261 MS patients with MR imaging at baseline and after 1-2years, and Expanded Disability Status Scale (EDSS) scoring at baseline and after 10years. Annualised whole brain atrophy, central brain atrophy rates and T2 lesion volumes were calculated. Patients were categorised by baseline diagnosis as primary progressive MS (n=77), clinically isolated syndromes (n=18), relapsing-remitting MS (n=97) and secondary progressive MS (n=69). Relapse onset patients were classified as minimally impaired (EDSS=0-3.5, n=111) or moderately impaired (EDSS=4-6, n=55) according to their baseline disability (and regardless of disease type). Linear regression models tested whether whole brain and central atrophy, lesion volumes at baseline, follow-up and lesion volume change predicted 10 year EDSS and MS Severity Scale scores. Results In the whole patient group, whole brain and central atrophy predicted EDSS at 10years, corrected for imaging protocol, baseline EDSS and disease modifying treatment. The combined model with central atrophy and lesion volume change as MRI predictors predicted 10 year EDSS with R-2=0.74 in the whole group and R-2=0.72 in the relapse onset group. In subgroups, central atrophy was predictive in the minimally impaired relapse onset patients (R-2=0.68), lesion volumes in moderately impaired relapse onset patients (R-2=0.21) and whole brain atrophy in primary progressive MS (R-2=0.34). Conclusions This large multicentre study points to the complementary predictive value of atrophy and lesion volumes for predicting long term disability in MS.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Atrophy -
Brain - pathology
Demyelinating Diseases - diagnosis
Disability Evaluation -
Female -
Humans -
Image Interpretation, Computer-Assisted -
Linear Models -
Longitudinal Studies -
Magnetic Resonance Imaging -
Male -
Middle Aged -
Multiple Sclerosis, Chronic Progressive - diagnosis
Multiple Sclerosis, Relapsing-Remitting - diagnosis
Prognosis -
Retrospective Studies -

Find related publications in this database (Keywords)
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