Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wolf, G; Aigner, RM; Schaffler, G; Langsenlehner, U; Renner, W; Samonigg, H; Yazdani-Biuki, B; Krippl, P.
The 936C>T polymorphism of the gene for vascular endothelial growth factor is associated with 18F-fluorodeoxyglucose uptake.
BREAST CANCER RES TREAT. 2004; 88(3): 205-208.
Doi: 10.1007/s10549-004-0724-2
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- Führende Autor*innen der Med Uni Graz
- Renner Wilfried
- Co-Autor*innen der Med Uni Graz
- Aigner Reingard
- Krippl Peter
- Langsenlehner Uwe
- Samonigg Hellmut
- Schaffler Gottfried
- Yazdani-Biuki Babak
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- Abstract:
- Background: Positron emission tomography (PET) is a an important technology for detection and staging of breast cancer. The method is based upon assessment of glucose metabolism using the 18F-fluorodeoxyglucose (18F-FDG) as glucose analog. A strong variability of 18F-FDG uptake by breast cancer tissue has been reported, the reason for which is not fully understood but may involve vascular density and integrity. A 936C>T polymorphism in the gene for the vascular endothelial growth factor (VEGF) has been associated with VEGF plasma levels and breast cancer risk. Methods: To analyze the role of this polymorphism for 18F-FDG uptake in breast cancer patients, we determined the VEGF genotype in 37 patients in whom PET was performed for detection of metastases. An 18F-FDG uptake score of 1 (low uptake), 2 (medium uptake) or 3 (high uptake) was assigned to each patient. Results: VEGF CC, CT and TT genotypes were found in 28, 8 and 1 patient. Uptake score of 1 was found in three patients, score 2 in 12 patients and score 3 in 22 patients. VEGF genotype was significantly associated with FDG uptake score (chi(2) test, p=0.007). The number of 936-T alleles correlated with a lower 18F-FDG uptake score (Spearman correlation test, p=0.032). Conclusion: In the present study the common VEGF 936C>T polymorphisms had a major impact on 18F-FDG uptake in breast cancer patients. If this result can be confirmed in following studies, it might have strong relevance for the use of PET as diagnostic tool.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Breast - metabolism
- Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - radionuclide imaging
- Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - radionuclide imaging
- Female -
- Fluorodeoxyglucose F18 - pharmacokinetics
- Glucose - metabolism
- Humans -
- Middle Aged -
- Polymorphism, Genetic -
- Positron-Emission Tomography -
- Radiopharmaceuticals - pharmacokinetics
- Vascular Endothelial Growth Factor A - genetics
- Find related publications in this database (Keywords)
- breast cancer
- genetics
- PET