Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tomaschitz, A; Pilz, S; Pieske, B; Ritz, E; März, W; Meinitzer, A; Dobnig, H; Amrein, K; Kienreich, K; Verheyen, N; Kraigher-Krainer, E; Drechsler, C; Colantonio, C; Wagner, D; Fahrleitner-Pammer, A.
Circulating aldosterone and mortality in female nursing home residents.
Exp Gerontol. 2013; 48(3):313-318
Doi: 10.1016/j.exger.2013.01.004
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- Führende Autor*innen der Med Uni Graz
- Tomaschitz Andreas
- Co-Autor*innen der Med Uni Graz
- Amrein Karin
- Colantonio Caterina
- Dobnig Harald
- Fahrleitner-Pammer Astrid
- Kienreich Katharina
- Kraigher-Krainer Elisabeth
- März Winfried
- Meinitzer Andreas
- Pieske Burkert Mathias
- Pilz Stefan
- Verheyen Nicolas Dominik
- Wagner Doris
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- Abstract:
- To date studies evaluating the relation between circulating aldosterone levels and mortality in elderly female individuals are lacking. We therefore aimed to assess the relationship between circulating aldosterone levels and mortality in a population-based cohort study of female nursing home residents. Individuals aged 70years and older were recruited from 95 nursing homes in Austria. Participants were enrolled and followed up by mobile study teams. All participants underwent an extensive health examination and were followed until death or end of the study. Serum aldosterone concentration (SAC) was measured at baseline after exclusion of twenty seven patients taking mineralocorticoid-receptor (MR) blockers. Median SAC was 171.1 (IQR: 103.2-303.4) pg/mL (normal range: 30-400) in 471 female individuals (mean age: 83.7±6.2years). After a median follow-up of 27±8months, a total of 121 (25.7%) participants died. In multivariable Cox proportional hazard analysis, SAC levels stratified in quartiles were significantly associated with all-cause mortality. Compared with the reference (first) SAC quartile, the Cox proportional hazard ratio (confidence interval 95%) for the fourth SAC quartiles was 1.94, 95% CI=1.08-3.46, p=0.026. We found statistically significant interaction terms between SAC-related mortality and the presence of advanced heart failure (NYHA functional class III; p=0.038), HbA1c (p=0.043) and eGFR levels (p=0.030). Higher circulating aldosterone levels are related to an increased mortality risk in elderly female nursing home residents. Interventional studies are needed to assess the potential influence of MR blockade on "hard" clinical outcomes in individuals aged 70years and older. Copyright © 2013 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Aldosterone - blood
- Aldosterone - epidemiology
- Biomarkers - blood
- Female -
- Follow-Up Studies -
- Glomerular Filtration Rate - physiology
- Heart Failure - blood Heart Failure - mortality
- Hemoglobin A, Glycosylated - metabolism
- Homes for the Aged -
- Humans -
- Mortality -
- Nursing Homes -
- Prospective Studies -
- Find related publications in this database (Keywords)
- Aldosterone
- Mortality
- Elderly female individuals
- Nursing home residents
- Heart failure