Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Szkandera, J; Kiesslich, T; Haybaeck, J; Gerger, A; Pichler, M.
Hedgehog signaling pathway in ovarian cancer.
Int J Mol Sci. 2013; 14(1):1179-1196
Doi: 10.3390/ijms14011179
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- Führende Autor*innen der Med Uni Graz
- Pichler Martin
- Szkandera Joanna
- Co-Autor*innen der Med Uni Graz
- Gerger Armin
- Haybäck Johannes
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- Abstract:
- Despite advances in surgical and chemotherapeutic treatment options, less than 50% of patients with advanced-stage ovarian cancer survive five years after initial diagnosis. In this regard, novel treatment approaches are warranted utilizing molecularly targeted therapies directed against particular components of specific signaling pathways which are required for tumor development and progression. One molecular pathway of interest is the hedgehog (Hh) signaling pathway. Activation of the Hh pathway has been observed in several cancer types, including ovarian cancer. This review highlights the crucial role of Hh signaling in the development and progression of ovarian cancer and might lead to a better understanding of the Hh signaling in ovarian tumorigenesis, thus encouraging the investigation of novel targeted therapies.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Transformation, Neoplastic - drug effects
- Disease Progression -
- Female -
- Hedgehog Proteins - antagonists & inhibitors
- Humans -
- Models, Biological -
- Molecular Targeted Therapy - methods
- Ovarian Neoplasms - drug therapy
- Signal Transduction -
- Find related publications in this database (Keywords)
- Hedgehog pathway
- ovarian cancer
- carcinogenesis
- targeted therapy