Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Homayoon, N; Ropele, S; Hofer, E; Schwingenschuh, P; Seiler, S; Schmidt, R.
Microstructural tissue damage in normal appearing brain tissue accumulates with Framingham Stroke Risk Profile Score: magnetization transfer imaging results of the Austrian Stroke Prevention Study.
Clin Neurol Neurosurg. 2013; 115(8):1317-1321
Doi: 10.1016/j.clineuro.2012.12.016
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- Führende Autor*innen der Med Uni Graz
- Homayoon Nina
- Schmidt Reinhold
- Co-Autor*innen der Med Uni Graz
- Hofer Edith
- Ropele Stefan
- Schwingenschuh Petra
- Seiler Stephan
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- Abstract:
- Background and purpose: Magnetization transfer imaging detects cerebral microstructural tissue alterations. We examined the association between the Framingham Stroke Risk Profile (FSRP) score and magnetization transfer imaging (MTI) measures in pathological and normal appearing brain tissue in clinically normal elderly subjects to determine if stroke risk leads to brain tissue destruction beyond what is visible in conventional MRI scans. Methods: The study cohort is from the Austrian Stroke Prevention Study (ASPS). A total of 316 subjects underwent MTI and had a complete risk factor assessment sufficient to calculate the FSRP score. There were 205 women and 111 men with a mean age of 70.2 years ranging from 54 to 82 years. Subjects were grouped into four categories of stroke risk probability ranging from 3% to 88% for men and 1% to 84% for women. Results: A higher FSRP score was significantly and independently associated with a MTR peak position shift indicating global microstructural alterations in brain tissue (BT) and in normal appearing brain tissue (NABT). The mean MTR in white matter hyperintensities (WMH) correlated inversely with increasing stroke risk. Age explained most of the variance in MTR peak position, all other risk factors of the FSRP score contributed significantly but explained an additional 2% of the variance of this MRI measure, only. Conclusion: Increasing risk for stroke leads to microstructural brain changes invisible by standard MRI. The validity, the underlying pathogenic mechanisms and the clinical importance of these abnormalities needs to be further determined. (C) 2012 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Aging - pathology
- Aging -
- Brain - pathology
- Cerebrovascular Disorders - epidemiology
- Cohort Studies -
- Data Interpretation, Statistical -
- Female -
- Humans -
- Image Processing, Computer-Assisted -
- Magnetic Resonance Imaging - methods
- Male -
- Middle Aged -
- Regression Analysis -
- Risk Factors -
- Stroke - pathology
- Find related publications in this database (Keywords)
- Magnetic resonance imaging
- Magnetization transfer imaging
- Cerebrovascular risk factors
- Stroke