Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sipido, KR; Acsai, K; Antoons, G; Bito, V; Macquaide, N.
T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange.
Adv Exp Med Biol. 2013; 961(3):375-383
Doi: 10.1007/978-1-4614-4756-6_32
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- Co-Autor*innen der Med Uni Graz
- Antoons Gudrun
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- Abstract:
- The Na(+)/Ca(2+) exchanger (NCX) is a key regulator of intracellular Ca(2+) in cardiac myocytes, predominantly contributing to Ca(2+) removal during the diastolic relaxation process but also modulating excitation-contraction coupling. NCX is preferentially located in the T-tubules and can be close to or within the dyad, where L-type Ca(2+) channels face ryanodine receptors (RyRs), the Ca(2+) release channels of the sarcoplasmic reticulum. However, especially in larger animals, not all RyRs are in dyads or adjacent to T-tubules, and a substantial fraction of Ca(2+) release from the sarcoplasmic reticulum thus occurs at distance from NCX. This chapter deals with the functional consequences of NCX location and how NCX can modulate diastolic and systolic Ca(2+) events. The loss of T-tubules and the effects on RyR function and NCX modulation are explored, as well as quantitative measurement of local Ca(2+) gradients at the level of the dyadic space.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcium - metabolism
- Calcium Channels, L-Type - genetics Calcium Channels, L-Type - metabolism
- Humans -
- Muscle Proteins - genetics Muscle Proteins - metabolism
- Myocytes, Cardiac - metabolism
- Ryanodine Receptor Calcium Release Channel - genetics Ryanodine Receptor Calcium Release Channel - metabolism
- Sarcoplasmic Reticulum - genetics Sarcoplasmic Reticulum - metabolism
- Sodium - metabolism
- Sodium-Calcium Exchanger - genetics Sodium-Calcium Exchanger - metabolism
- Find related publications in this database (Keywords)
- Ryanodine receptor
- Na+/Ca2+ exchange
- T-tubules
- Hypertrophy
- Heart
- Myocardial infarction