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Pilz, S; Kienreich, K; Rutters, F; de Jongh, R; van Ballegooijen, AJ; Grübler, M; Tomaschitz, A; Dekker, JM.
Role of vitamin D in the development of insulin resistance and type 2 diabetes.
Curr Diab Rep. 2013; 13(2):261-270 Doi: 10.1007/s11892-012-0358-4
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Führende Autor*innen der Med Uni Graz
Pilz Stefan
Co-Autor*innen der Med Uni Graz
Grübler Martin
Kienreich Katharina
Tomaschitz Andreas

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Vitamin D deficiency is mainly a consequence of insufficient sunlight induced vitamin D production in the skin and has been associated with various chronic diseases including type 2 diabetes. Experimental data have shown that vitamin D is important for glucose induced insulin secretion, improves insulin resistance, and exerts anti-inflammatory actions. Epidemiological studies have largely documented that a poor vitamin D status is associated with higher risk of insulin resistance and type 2 diabetes. The majority of randomized controlled trials (RCTs) in healthy or prediabetic individuals have, however, failed to demonstrate relevant vitamin D effects on insulin resistance or diabetes incidence. In patients with type 2 diabetes, a few RCTs reported some moderate effects of vitamin D on glycemic control and insulin resistance. While these findings warrant further in-depth studies, the current evidence is insufficient to recommend vitamin D supplementation for the prevention or treatment of type 2 diabetes.
Find related publications in this database (using NLM MeSH Indexing)
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - prevention & control
Humans -
Insulin Resistance - physiology
Vitamin D - metabolism
Vitamin D - therapeutic use
Vitamin D Deficiency - complications

Find related publications in this database (Keywords)
Vitamin D
Insulin resistance
Glucose metabolism
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