Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pilz, S; Kienreich, K; Tomaschitz, A; Ritz, E; Lerchbaum, E; Obermayer-Pietsch, B; Matzi, V; Lindenmann, J; März, W; Gandini, S; Dekker, JM.
Vitamin D and Cancer Mortality: Systematic Review of Prospective Epidemiological Studies.
Anticancer Agents Med Chem. 2013; 13(1):107-117
Doi: 10.2174/187152013804487407
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Pilz Stefan
- Co-Autor*innen der Med Uni Graz
- Kienreich Katharina
- Lerchbaum Elisabeth
- Lindenmann Jörg
- März Winfried
- Matzi Veronika
- Obermayer-Pietsch Barbara
- Tomaschitz Andreas
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- Abstract:
- Accumulating evidence from experimental and epidemiological studies suggests that vitamin D deficiency might be a causal risk factor for cancer and therewith associated mortality. We performed a systematic review in Medline up to February 2012 to identify prospective studies on 25-hydroxyvitamin D (25[OH]D) and cancer mortality as well as on 25(OH)D and survival in cancer patients. Our search retrieved 13 studies on cancer-specific mortality and 20 studies on overall mortality in cancer patients. Data on 25(OH)D and cancer mortality were mainly derived from general populations. The results were inconsistent and yielded either no, inverse or positive associations. By contrast, the majority of studies in cancer patients showed that patients with higher 25(OH)D levels had a decreased risk of mortality. This relationship was particularly evident in cohorts of colorectal cancer patients. In contrast, there was no indication for increased mortality risk with higher vitamin D levels in any cancer cohort. In conclusion, the relationship of vitamin D status and cancerspecific mortality is still unclear and warrants further studies. Our results provide a strong rationale to perform prospective randomized controlled studies to document a potential effect of vitamin D supplementation on survival in cancer patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans -
- Neoplasms - epidemiology Neoplasms - mortality
- Prospective Studies -
- Randomized Controlled Trials as Topic -
- Vitamin D - analogs & derivatives Vitamin D - blood
- Find related publications in this database (Keywords)
- Vitamin D
- Cancer
- Death
- Mortality
- 25(OH)D
- Prospective
- Calcidiol
- Calcitriol
- Randomized controlled trial
- Epidemiological
- RCT
- WHI
- Colorectal cancer
- Outcome
- 1,25(OH)2D
- Survival
- Follow-up