Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pichler, M; Hutterer, GC; Chromecki, TF; Jesche, J; Kampel-Kettner, K; Groselj-Strele, A; Hoefler, G; Pummer, K; Zigeuner, R.
Comparison of the 2002 and 2010 TNM classification systems regarding outcome prediction in clear cell and papillary renal cell carcinoma.
Histopathology. 2013; 62(2):237-246
Doi: 10.1111/his.12001
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Hutterer Georg
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Chromecki Thomas
- Groselj-Strele Andrea
- Höfler Gerald
- Jesche-Chromecki Johanna
- Pummer Karl
- Strini Karin
- Zigeuner Richard
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- Abstract:
- Pichler M, Hutterer G C, Chromecki T F, Jesche J, Kampel-Kettner K, Groselj-Strele A, Hoefler G, Pummer K & Zigeuner R (2013) Histopathology 62, 237-246 Comparison of the 2002 and 2010 TNM classification systems regarding outcome prediction in clear cell and papillary renal cell carcinoma Aims: A novel version of the tumournodemetastasis (TNM) classification system for renal cell carcinoma (RCC) was introduced in 2010, although the prognostic significance with regard to different histological subtypes has not been explored. Therefore, the aim of our study was to compare the predictive ability of the 2002 and 2010 versions of the TNM classification system for clear cell and papillary RCC. Methods and results: Data from 2263 consecutive clear cell and 309 papillary RCC patients, operated at a single tertiary academic centre, were evaluated. According to TNM 2010, statistically significant differences for cancer-specific survival (CSS) were observed for pT1a versus pT1b (P < 0.001) and pT3a versus pT3b (P < 0.004) in clear cell RCC; and pT1b versus pT2a (P = 0.002) and pT3b versus pT3c (P = 0.046) in papillary RCC. The c-index for CSS in clear cell RCC was 0.74 and 0.73, and in papillary RCC 0.79 and 0.78, for the 2002 and 2010 versions of the TNM classification system, respectively. Conclusions: According to our data, the predictive ability of the 2010 version of the TNM classification system regarding CSS is not superior to the 2002 version, either in clear cell or in papillary RCC.
- Find related publications in this database (using NLM MeSH Indexing)
- Academic Medical Centers -
- Aged -
- Aged - epidemiology
- Carcinoma, Papillary - classification Carcinoma, Papillary - mortality Carcinoma, Papillary - secondary
- Carcinoma, Renal Cell - classification Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - secondary
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Kidney Neoplasms - classification Kidney Neoplasms - mortality Kidney Neoplasms - pathology
- Lymph Nodes - pathology
- Lymphatic Metastasis -
- Male -
- Middle Aged -
- Neoplasm Grading -
- Nephrectomy -
- Predictive Value of Tests -
- Prognosis -
- Retrospective Studies -
- Survival Rate -
- Tertiary Care Centers -
- Find related publications in this database (Keywords)
- predictive ability
- prognosis
- renal cell carcinoma
- TNM classification